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The Strength of the Genetic Effect

Is There Room for an Environmental Influence in the Aetiology of Schizophrenia?

Published online by Cambridge University Press:  02 January 2018

Peter Mcguffin ,
Philip Asherson ,
Michael Owen  and
Anne Farmer
Peter Mcguffin*
Affiliation:
Department of Psychological Medicine, University of Wales College of Medicine, Cardiff CF4 4XN
Philip Asherson
Affiliation:
Department of Psychological Medicine, University of Wales College of Medicine
Michael Owen
Affiliation:
Departments of Medical Genetics and Psychological Medicine, University of Wales College of Medicine
Anne Farmer
Affiliation:
Departments of Psychological Medicine and Postgraduate Education, University of Wales College of Medicine
*
∗Correspondence
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Abstract

The evidence for a genetic contribution to schizophrenia is compelling. However, the pattern of inheritance is complex and it is usually assumed that environmental factors also have a role that will eventually be identified. We argue that this is not necessarily the case. While a hypothesis combining genetic diathesis with environmental stress cannot be disproved, it is also possible that ‘non-genetic’ factors consist entirely of stochastic events affecting gene expression or structure.

Type
Hypotheses
Information
The British Journal of Psychiatry , Volume 164 , Issue 5 , May 1994 , pp. 593 - 599
Copyright
Copyright © 1994 The Royal College of Psychiatrists 

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