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Sight and Insight: Regional Cerebral Metabolic Activity in Schizophrenia Visualised by Positron Emission Tomography, and Competing Neurodevelopmental Perspectives

Published online by Cambridge University Press:  02 January 2018

John L. Waddington
John L. Waddington*
Affiliation:
Royal College of Surgeons in Ireland, St Stephen's Green, Dublin 2, Ireland
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Extract

Over the past several years there has emerged a family of highly sophisticated but technically complex procedures for the visualisation of a range of cerebral functions in living man (Andreasen, 1988). The images they produce are so beguiling not just because of their potential to give new insights into the pathophysiology and treatment of major psychiatric disorders, but because they convey information through a quite fundamental modality: people are only convinced by what they can see. However, initial applications of such new technology have appeared just as likely to generate new questions and contradictions as to provide answers to current issues. This is readily illustrated by recent studies on the imaging of brain dopamine receptors in schizophrenic patients by positron emission tomography (PET) (see Waddington, 1989a).

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Information
The British Journal of Psychiatry , Volume 156 , Issue 5 , May 1990 , pp. 615 - 619
Copyright
Copyright © Royal College of Psychiatrists, 1990 

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References

Andreasen, N. C. (1988) Brain imaging: applications in psychiatry. Science, 239, 1381–1388.CrossRefGoogle ScholarPubMed
Andreasen, N. C., Ehrhardt, J., Yuh, W., et al (1989) Magnetic resonance imaging in schizophrenia: an update. In Schizophrenia: Scientific Progress (eds Schulz, S. C. & Tamminga, C. A.). New York: Oxford University Press.Google Scholar
Baxter, L. R., Schwartz, J. M., Phelps, M. E., et al (1989) Reduction of prefrontal cortex glucose metabolism common to three types of depression. Archives of General Psychiatry, 46, 243–250.CrossRefGoogle ScholarPubMed
Berman, K. F., Weinberger, D. R., Shelton, R. C., et al (1987) A relationship between anatomical and physiological brain pathology in schizophrenia: lateral cerebral ventricular size predicts cortical blood flow. American Journal of Psychiatry, 144, 1277–1282.Google ScholarPubMed
Buchsbaum, M. S., Ingvar, D. H., Kessler, R., et al (1982) Cerebral glucography with positron tomography: use in normal subjects and in patients with schizophrenia. Archives of General Psychiatry, 39, 251–259.CrossRefGoogle ScholarPubMed
Buchsbaum, M. S., DeLisi, L. E., Holcomb, H. H., et al (1984) Anteroposterior gradients in cerebral glucose use in schizophrenia and affective disorders. Archives of General Psychiatry, 41, 1159–1166.CrossRefGoogle ScholarPubMed
Buchsbaum, M. S., Wu, J., DeLisi, L. E., et al (1986) Frontal cortex and basal ganglia metabolic rates assessed by positron emission tomography with 18F-2–deoxyglucose in affective illness. Journal of Affective Disorders, 10, 137–152.CrossRefGoogle Scholar
Buchsbaum, M. S., Wu, J., DeLisi, L. E., et al (1987) Positron emission tomography studies of basal ganglia and somatosensory cortex neuroleptic drug effects: differences between normal controls and schizophrenic patients. Biological Psychiatry, 22, 479–494.CrossRefGoogle ScholarPubMed
Buchsbaum, M. S., Haier, R. J. & Wu, J. (1989) Specificity of positron emission tomographic findings in schizophrenia. Schizophrenia Research, 2, 108.CrossRefGoogle Scholar
Cohen, B. M., Babb, S., Campbell, A., et al (1988) Persistence of haloperidol in the brain. Archives of General Psychiatry, 45, 879–880.CrossRefGoogle ScholarPubMed
Cohen, R. M., Semple, W. E., Gross, M., et al (1987) Dysfunction in a prefrontal substrate of sustained attention in schizophrenia. Life Sciences, 40, 2031–2039.CrossRefGoogle Scholar
Cohen, R. M., Semple, W. E., Gross, M., et al (1988) The effect of neuroleptics on dysfunction in a prefrontal substrate of sustained attention in schizophrenia. Life Sciences, 43, 1141–1150.CrossRefGoogle Scholar
DeLisi, L. E., Buchsbaum, M. S., Holcomb, H. H., et al (1985a) Clinical correlates of decreased anteroposterior metabolic gradients in positron emission tomography (PET) of schizophrenic patients. American Journal of Psychiatry, 142, 78–81.Google ScholarPubMed
DeLisi, L. E., Holcomb, H. H., Cohen, R. M., et al (1985b) Positron emission tomography in schizophrenic patients with and without neuroleptic medication. Journal of Cerebral Blood Flow and Metabolism, 5, 201–206.CrossRefGoogle ScholarPubMed
DeLisi, L. E., Buchsbaum, M. S., Holcomb, H. H., et al (1989) Increased temporal lobe glucose use in chronic schizophrenic patients. Biological Psychiatry, 25, 835–851.CrossRefGoogle ScholarPubMed
Early, T. S., Reiman, E. M., Raichle, M. E., et al (1987) Left globus pallidus abnormality in never-medicated patients with schizophrenia. Proceedings of the National Academy of Sciences of the United States of America, 84, 561–563.CrossRefGoogle ScholarPubMed
Farkas, T., Wolf, A. P., Jaeger, J., et al (1984) Regional brain glucose metabolism in chronic schizophrenia: a positron emission transaxial tomographic study. Archives of General Psychiatry, 41, 293–300.CrossRefGoogle ScholarPubMed
Feinberg, I. (1982) Schizophrenia: caused by a fault in programmed synaptic elimination during adolescence? Journal of Psychiatric Research, 17, 319–334.CrossRefGoogle ScholarPubMed
Gitlin, M. J., Midha, K. K., Fogelson, D., et al (1988) Persistence of fluphenazine in plasma after decanoate withdrawal. Journal of Clinical Psychopharmacology, 8, 53–56.CrossRefGoogle ScholarPubMed
Gur, R. E., Resnick, S. M., Alavi, A., et al (1987a) Regional brain function in schizophrenia. I. A positron emission tomography study. Archives of General Psychiatry, 44, 119–125.CrossRefGoogle Scholar
Gur, R. E., Resnick, S. M., Gur, R. C., et al (1987b) Regional brain function in schizophrenia. II. Repeated evaluation with positron emission tomography. Archives of General Psychiatry, 44, 126–129.CrossRefGoogle ScholarPubMed
Holcomb, H. H., Links, J., Smith, C., et al (1989) Positron emission tomography. In Brain Imaging (ed. Andreasen, N. C.). Washington, DC: American Psychiatric Press.Google Scholar
Jorgensen, O. S. (1988) Neural cell adhesion molecule (NCAM) and prealbumin in cerebrospinal fluid from depressed patients. Acta Psychiatrica Scandinavica, 78 (suppl. 345), 29–37.CrossRefGoogle Scholar
Jorgensen, O. S., Gjerris, A. & Rafaelsen, O. J. (1984) Increased dilution of brain extracellular fluid in CSF of depressed and schizophrenic patients marked by neuronal D2-like protein concentration. Clinical Neuropharmacology, 7 (suppl. 1), 158–159.CrossRefGoogle Scholar
Kling, A. S., Metter, E. J., Riege, W. H., et al (1986) Comparison of PET measurement of local brain glucose metabolism and CAT measurement of brain atrophy in chronic schizophrenia and depression. American Journal of Psychiatry, 143, 175–180.Google ScholarPubMed
Lantos, P. L. (1988) The neuropathology of schizophrenia: a critical review of recent work. In Schizophrenia: The Major Issues (eds Bebbington, P. & McGuffin, P.). Oxford: Heinemann.Google Scholar
Lyons, F., Martin, M. L., Maguire, C., et al (1988) The expression of an NCAM serum fragment is positively correlated with severity of negative features in type II schizophrenia. Biological Psychiatry, 23, 769–775.CrossRefGoogle ScholarPubMed
Murray, R. M. & Lewis, S. W. (1987) Is schizophrenia a neurodevelopmental disorder? British Medical Journal, 295, 681–682.CrossRefGoogle ScholarPubMed
Schwartz, J. M., Baxter, L. R., Mazziotta, J. C., et al (1987) The differential diagnosis of depression: relevance of positron emission tomography studies of cerebral glucose metabolism to the bipolar-unipolar dichotomy. Journal of the American Medical Association, 258, 1368–1374.CrossRefGoogle Scholar
Shelton, R. C., Karson, C. N., Doran, A. R., et al (1988) Cerebral structural pathology in schizophrenia. American Journal of Psychiatry, 145, 154–163.Google ScholarPubMed
Sheppard, G., Gruzelier, J., Manchanda, R., et al (1983) 15O positron emission tomographic scanning in predominantly never-treated acute schizophrenic patients. Lancet, ii, 1448–1452.CrossRefGoogle Scholar
Suddath, R. L., Casanova, M. F., Goldberg, T. E., et al (1989) Temporal lobe pathology in schizophrenia: a quantitative magnetic resonance imaging study. American Journal of Psychiatry, 146, 464–472.Google ScholarPubMed
Szechtman, H., Nahmias, C., Garnett, S., et al (1988) Effect of neuroleptics on altered cerebral glucose metabolism in schizophrenia. Archives of General Psychiatry, 45, 523–532.CrossRefGoogle ScholarPubMed
Videen, T. O., Perlmutter, J. S., Mintun, M. A., et al (1988) Regional correction of positron emission tomography data for the effects of cerebral atrophy. Journal of Cerebral Blood Flow and Metabolism, 8, 662–670.CrossRefGoogle ScholarPubMed
Volkow, N. D., Brodie, J. D., Wolf, A. P., et al (1986) Brain metabolism in patients with schizophrenia before and after acute neuroleptic administration. Journal of Neurology, Neurosurgery and Psychiatry, 49, 1199–1202.CrossRefGoogle ScholarPubMed
Volkow, N. D., Wolf, A. P., Van Gelder, P., et al (1987) Phenomenological correlates of metabolic activity in 18 patients with chronic schizophrenia. American Journal of Psychiatry, 144, 151–158.Google ScholarPubMed
Waddington, J. L. (1988) The ageing brain, neuroleptic drugs and the enigma of schizophrenia. Irish Journal of Medical Science, 157, 135–141.CrossRefGoogle ScholarPubMed
Waddington, J. L. (1989a) Sight and insight: brain dopamine receptor occupancy by neuroleptics visualised in living schizophrenic patients by positron emission tomography. British Journal of Psychiatry, 154, 433–436.CrossRefGoogle ScholarPubMed
Waddington, J. L. (1989b) CT and MRI abnormalities in schizophrenia: the new developmental biology of psychosis? Irish Journal of Psychological Medicine, 6, 19–21.CrossRefGoogle Scholar
Waddington, J. L. & Gamble, S. J. (1981) Prolonged dopamine receptor blockade in rats after termination of long-term depot fluphenazine. Lancet, i, 1375–1376.CrossRefGoogle Scholar
Weinberger, D. R. (1987) Implications of normal brain development for the pathogenesis of schizophrenia. Archives of General Psychiatry, 44, 660–669.CrossRefGoogle ScholarPubMed
Weinberger, D. R. (1988) Schizophrenia and the frontal lobe. Trends in Neurosciences, 11, 367–370.CrossRefGoogle ScholarPubMed
Weinberger, D. R., Berman, K. F. & Zec, R. F. (1986) Physiological dysfunction of dorsolateral prefrontal cortex in schizophrenia. I. Regional cerebral blood flow evidence. Archives of General Psychiatry, 43, 114–124.CrossRefGoogle ScholarPubMed
Weinberger, D. R., Berman, K. F. & Illowsky, B. P. (1988) Physiological dysfunction of dorsolateral prefrontal cortex in schizophrenia. III. A new cohort and evidence for a monoaminergic mechanism. Archives of General Psychiatry, 45, 609–615.CrossRefGoogle Scholar
Wistedt, B., Wiles, D. & Kolakowska, T. (1981) Slow decline of plasma drug and prolactin levels after discontinuation of chronic treatment with depot neuroleptics. Lancet, i, 1163.CrossRefGoogle Scholar
Wolkin, A., Jaeger, J., Brodie, J. D., et al (1985) Persistence of cerebral metabolic abnormalities in chronic schizophrenia as determined by positron emission tomography. American Journal of Psychiatry, 142, 564–571.Google ScholarPubMed
Wolkin, A., Angrist, B., Wolf, A., et al (1987) Effects of amphetamine on local cerebral metabolism in normal and schizophrenic subjects as determined by positron emission tomography. Psychopharmacology, 92, 241–246.CrossRefGoogle ScholarPubMed
Wolkin, A., Angrist, B., Wolf, A., et al (1988) Low frontal glucose utilisation in chronic schizophrenia: a replication study. American Journal of Psychiatry, 145, 251–253.Google ScholarPubMed
Yoshii, F., Barker, W. W., Chang, J. Y., et al (1988) Sensitivity of cerebral glucose metabolism to age, gender, brain volume, brain atrophy, and cerebrovascular risk factors. Journal of Cerebral Blood Flow and Metabolism, 8, 654–661.CrossRefGoogle ScholarPubMed
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