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Serum Uric Acid and Cholesterol Levels in Mongoloid and Non-Mongoloid Oligophrenics

Published online by Cambridge University Press:  29 January 2018

L. M. Dalderup ,
H. Affourtit-Leeuw ,
P. A. F. van der Spek ,
G. H. M. Keller ,
H. J. Duin  and
H. de Iongh
L. M. Dalderup
Affiliation:
The Netherlands Institute of Nutrition, Wageningen
H. Affourtit-Leeuw
Affiliation:
The Netherlands Institute of Nutrition, Wageningen
P. A. F. van der Spek
Affiliation:
Psychiatric Hospital St. Bavo, Noordwijkerhout
G. H. M. Keller
Affiliation:
The Netherlands Institute of Nutrition, Wageningen
H. J. Duin
Affiliation:
Unilever Research Laboratory, Vlaardingen
H. de Iongh
Affiliation:
Unilever Research Laboratory, Vlaardingen
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Extract

A number of observations have been published with regard to elevated serum uric acid levels in patients with atherosclerotic (Eidlitz, 1961, 1962) and coronary disease (Gertler, Garn and Levine, 1951) and hyperuricaemia after myocardial infarction (Dreyfuss, 1959; Kohn and Prozan, 1959). Work has also been done on dominant traits for hyperuricaemia together with hypercholesterolaemia (Adlersberg, 1949; Harris-Jones, 1957; Salvini and Verdi, 1959; Schoenfeld and Goldberger, 1963). A greater incidence of cardiovascular diseases among gouty patients than among others has been noted (Gertler and Oppenheimer, 1953), as well as a tendency for spontaneous changes in the serum cholesterol level to be associated with changes of similar direction and magnitude in the serum uric acid level (Schoenfeld and Goldberger, 1963). In view of all these observations, an investigation was undertaken to ascertain whether the serum uric acid levels change with dietary fat composition as do the serum cholesterol levels.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 112 , Issue 482 , January 1966 , pp. 91 - 94
Copyright
Copyright © Royal College of Psychiatrists, 1966 

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References

1. Adlersberg, D. (1949). “Newer advances in gout.” Bull. New York Acad. Med., 25, 651–665.Google Scholar
2. Anderson, J. T., and Keys, A. (1956). “Cholesterol in serum and lipoprotein fractions; its measurement and stability.” Clin. Chem., 2, 145–159.Google Scholar
3. Appleton, M. D., Haab, W., Casey, P. J., Castellino, F. J., Schorr, J. M., and Miraglia, R. J. (1964). “Role of vitamin A in gamma globulin biosynthesis and uric acid metabolism of mongoloids.” Am. J. ment. Defic., 69, 324–327.Google Scholar
4. Chapman, M. J., and Stern, J. (1964). “Uric acid in Down's disease.” J. ment. Defic. Res., 8, 119–124.Google Scholar
5. Cobb, S., Dunn, J. P., Brooks, G., and Rodnan, G. P. (1961). “Serum urate levels in males by social class.” Arthritis and Rheum., 4, 412.Google Scholar
6. Dreyfuss, F. (1959). “Hyperuricemia and coronary disease.” (Heb.) Harefuah, 57, 329–332. Cited by Eidlitz, M.Google Scholar
7. Eidlitz, M. (1961). “Uric acid and atherosclerosis.” Lancet, ii, 1046–1047.Google Scholar
8. Eidlitz, M. (1962). “Uricosuric treatment in angina pectoris.” Ibid., ii, 1118.Google Scholar
9. Fuller, R. W., Luce, M. W., and Mertz, E. T. (1962). “Serum uric acid in mongolism.” Science, 137, 868.Google Scholar
10. Gertler, M. M., Garn, S. M., and Levine, S. A. (1951). “Serum uric acid in relation to age and physique in health and in coronary heart disease.” Ann. int. Med., 34, 1421–1431.Google Scholar
11. Gertler, M. M., and Oppenheimer, B. S. (1953). “Serum uric acid levels in men and women past age of 65 years.” J. Geront., 8, 465–471.CrossRefGoogle Scholar
12. Harris-Jones, J. N. (1957). “Hyperuricaemia and essential hypercholesteraemia.” Lancet, i, 857–860.Google Scholar
13. Iongh, H. de, Beerthuis, R. K., Hartog, C. den, Dalderup, L. M., Spek, P. A. F. van der. “The influence of some dietary fats on serum lipids in man.” Part I: Nutritio Dieta, 1965, in press; Part II: in preparation.Google Scholar
14. Kohn, P. M., and Prozan, G. B. (1959). “Hyperuricemia: relationship to hypercholesterolemia and acute myocardial infarction.” J. Amer. med. Ass., 170, 1909–1912.Google Scholar
15. Lennox, W. G. (1925). “Retention of uric acid during fasting.” J. biol. Chem., 66, 521–572.Google Scholar
16. Mertz, E. T., Fuller, R. W., and Concon, J. M. (1963). “Serum uric acid in young mongoloids.” Science, 141, 535.Google Scholar
17. Salvini, L., and Verdi, G. (1959). “Statistical study on correlation between blood level of cholesterol, beta/alpha lipoprotein ratio and uric acid of normal and atherosclerotic subjects.” Gerontologia, 3, 327–334.Google Scholar
18. Schoenfeld, M. R., and Goldberger, E. (1963). “Serum cholesterol—uric acid correlations.” Metabolism, 12, 714–717.Google Scholar
19. Seegmiller, J. E., Laster, L., Howell, R. R. (1963). “Biochemistry of uric acid and its relation to gout.” New England J. Med., 268, 712–716; 764–773; 821–827.Google Scholar
20. Stanbury, J. B., Wijngaarden, J. B., and Fredrickson, D. S. (1960). “Gout”, in Metabolic Basis of Inherited Disease. McGraw Hill, London, New York.Google Scholar
21. Stern, J., and Lewis, W. H. P. (1957). “The serum cholesterol level in children with mongolism and other mentally retarded children.” J. ment. Defic. Res., 1, 96–106.Google Scholar
22. Stetten, de W. Jr., and Hearon, J. Z. (1959). “Intellectual level measured by army classification battery and serum uric acid concentration.” Science, 129, 1737.Google Scholar
23. De Vries, L. A., and Daatselaar, J. J. (1955). “Modification of Folin's method of serum uric acid determination”, in Klinische Diagnostiek, part I, 281–282. E. Gorter and W. C de Graaff, Stenfert Kroese, Leiden.Google Scholar
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