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The Search for the Psychosis Gene

Published online by Cambridge University Press:  02 January 2018

T. J. Crow
T. J. Crow*
Affiliation:
Division of Psychiatry, Clinical Research Centre, Watford Road, Harrow, Middlesex HA1 3UJ
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Extract

The major psychoses remain an enigma. Affective and schizophrenic psychoses are apparently present (probably at about the same lifetime prevalence of approximately 2%) in all human societies. Yet their aetiology is obscure. While a genetic contribution is acknowledged by most authorities, few accept that genes are a sufficient explanation of causation because: onset is in adult life; psychosis – particularly schizophrenia – is associated with a substantial fertility disadvantage; and most cases lack a family history of illness. But genetic determination has to be considered because onset is determined by chronological age rather than environmental insult (Crow & Done, 1986), adoption away from a family with schizophrenia does not reduce risk of illness, and no plausible environmental precipitant of psychosis has been identified. The fact that psychosis occurs across widely differing climatic, industrial, and social environments without obvious variations in incidence suggests that the disease is relatively independent of the external milieu. The suggestion that birth injury is relevant has been tested in a prospective study (the National Child Development Study) and found wanting (Done et al, 1991).

Type
Molecular Biology Symposium
Information
The British Journal of Psychiatry , Volume 158 , Issue 5 , May 1991 , pp. 611 - 614
Copyright
Copyright © Royal College of Psychiatrists, 1991 

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