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Responses of Growth Hormone to Desipramine in Endogenous and Non-endogenous Depression

Published online by Cambridge University Press:  02 January 2018

Timothy G. Dinan  and
Siobhan Barry
Timothy G. Dinan*
Affiliation:
Department of Psychiatry, Trinity College Medical School, St James's Hospital, Dublin 8, Ireland
Siobhan Barry
Affiliation:
Department of Psychiatry, Trinity College Medical School, St James's Hospital, Dublin 8, Ireland
*
∗Correspondence
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Abstract

Desipramine, a monoamine reuptake inhibitor, was used to stimulate release of growth hormone (GH) in 29 DSM-III major depressives and in 10 healthy controls. Eighteen of the depressives showed a blunted response. The GH-stimulation test was unable to distinguish endogenous from non-endogenous patients. The 13 dexamethasone non-suppressors were more likely to have a blunted GH response than the 14 suppressors. The results indicate that at least a subset of non-endogenous depressives have significant neuroendocrine abnormality.

Type
Lecture
Information
The British Journal of Psychiatry , Volume 156 , Issue 5 , May 1990 , pp. 680 - 684
Copyright
Copyright © Royal College of Psychiatrists, 1990 

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