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Response of Depressive Symptoms to Nortriptyline, Phenelzine and Placebo

Published online by Cambridge University Press:  03 January 2018

Anastasios Georgotas ,
Robert E. Mccue ,
Eitan Friedman  and
Thomas B. Cooper
Anastasios Georgotas*
Affiliation:
Depression Studies Program
Robert E. Mccue
Affiliation:
Department of Psychiatry
Eitan Friedman
Affiliation:
New York University School of Medicine
Thomas B. Cooper
Affiliation:
Columbia University College of Physicians and Surgeons; Psychiatric Research, Analytical Psychopharmacology Laboratory, Nathan Kline Institute and New York State Psychiatric Institute
*
New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
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Extract

The effects of nortriptyline, phenelzine, and placebo on 13 symptoms of depression were compared in 75 patients, aged 55 or over, who were suffering from major depression. Nortriptyline and phenelzine were more effective than placebo in treating depression mood, guilt feelings, suicidal ideation, agitation, anxiety, loss of energy, and a.m. diurnal variation of mood. Nortriptyline was better than phenelzine or placebo in improving middle/late insomnia. Most of the symptoms did not show significant improvement until the fourth week of treatment.

Type
Papers
Information
The British Journal of Psychiatry , Volume 151 , Issue 1 , July 1987 , pp. 102 - 106
Copyright
Copyright © The Royal College of Psychiatrists 

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