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The Reproducibility of the Mecholyl Test

Published online by Cambridge University Press:  29 January 2018

Charles G. Ingram  and
Walter G. Brovins
Charles G. Ingram
Affiliation:
Department of Physiology, St. Salvators College, University of S. Andrews, Fife, Scotland
Walter G. Brovins
Affiliation:
Ypsilanti State Hospital, Ypsilanti, Michigan, U.S.A
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Extract

The blood pressure response to the injection of the parasympathomimetic drug methacholine (Mecholyl) has been used extensively in psychiatry to delineate various aspects of mental disease. Although originally used in diagnostic classification (Altman et al., 1943), its use, following the investigations of Funkenstein and his co-workers (1948, 1952), has more often been as an aid in prognosis or as a guide to the most useful type of somatic therapy. Investigations into this aspect of the test have resulted in many contradictory reports, and even after so many years there is still no agreement on the test's validity or usefulness.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 112 , Issue 483 , February 1966 , pp. 167 - 171
Copyright
Copyright © Royal College of Psychiatrists, 1966 

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References

Altman, L. I., Pratt, D., and Cotten, J. M. (1943). “Cardiovascular responses to acetyl-β-methyl choline in mental disorders.” J. nerv. ment. Dis., 97, 296–301.CrossRefGoogle Scholar
Altschule, M. (1953). Bodily Physiology in Mental and Emotional Disorders. New York: Grune & Stratton.Google Scholar
Blumbero, A. G. (1960). “Reproducibility of Mecholyl test.” Psychosom. Med., 22, 32–41.CrossRefGoogle Scholar
Feinberg, I. (1958). “Current status of the Funkenstein test.” Arch. Neurol. & Psychiat., 80, 488–501.CrossRefGoogle ScholarPubMed
Fisher, R. A. (1958). Statistical Methods for Research Workers. Edinburgh: Oliver & Boyd.Google Scholar
Funkenstein, D., and Greenblatt, M. (1948). “Autonomic nervous system changes following electric shock treatment.” J. nerv. ment. Dis., 106, 409–422.Google Scholar
Funkenstein, D., and Greenblatt, M. and Solomon, H. C. (1952). “An autonomic nervous test of prognostic significance in relation to electroshock treatment.” Psychosom. Med., 4, 347–362.Google Scholar
Gellhorn, E. (1957). Autonomic Balance and the Hypothalamus. Minneapolis: University Minnesota Press.Google Scholar
Gellhorn, E. and Miller, A. D. (1961). “Methacholine and noradrenaline tests.” Arch. gen. Psychiat., 67, 371–380.Google Scholar
Goodman, L., and Gilman, A. (1958). The Pharmacological Basis of Therapeutics. New York: Macmillan.Google Scholar
Grosz, H. J., and Miller, I. (1958). “Two factors limiting the reliability of the Mecholyl test: variability in day-to-day responses and dissimilarity between simultaneous bilateral determinations.” J. nerv. ment. Dis., 127, 417–429.CrossRefGoogle ScholarPubMed
Lotsof, E. J., and Yobst, J. (1957). “The reliability of the Mecholyl test.” Psychosom. Med., 19, 370–373.Google Scholar
Mass, J. W. (1958). “Reliability of Mecholyl test.” Arch. Neurol. & Psychiat., 79, 585–589.Google Scholar
Nelson, R., and Gellhorn, E. (1957). “The action of autonomic drugs on normal persons and neuropsychiatric patients: the role of age.” Psychosom. Med., 486–494.CrossRefGoogle Scholar
Sloane, R. B., Lewis, D. J., and Slater, P. (1957). “Reliability of epinephrine-methacholine (Mecholyl) testing.” Arch. Neurol. & Psychiat., 78, 294–300.Google Scholar
Weckowicz, T. E. (1956). “Reliability of Mecholyl test.” Arch. Neurol. & Psychiat., 76, 109–114.Google Scholar
Wiggers, C. J. (1951). “Recommendations for human blood pressure determination by sphygmomanometer.” J. Amer. med. Assoc., 147, 632–643.Google Scholar
Wilder, J. (1950). “The law of initial values.” Psychosom. Med., 12, 392–398.Google Scholar
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