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The Relationship of Schizophrenic Births to 16 Infectious Diseases

Published online by Cambridge University Press:  02 January 2018

E. O'Callaghan ,
P. C. Sham ,
N. Takei ,
G. Murray ,
G. Glover ,
E. H. Hare  and
R. M. Murray
E. O'Callaghan
Affiliation:
Cluain Mhuire Family Centre, Blackrock, Co. Dublin
P. C. Sham
Affiliation:
Genetic Section, Institute of Psychiatry, London
N. Takei
Affiliation:
Genetic Section, Institute of Psychiatry, London
G. Murray
Affiliation:
Genetic Section, Institute of Psychiatry, London
G. Glover
Affiliation:
Department of Community Medicine, Westminster Hospital, London
E. H. Hare
Affiliation:
The Bethlem Royal and Maudsley Hospitals, London
R. M. Murray*
Affiliation:
Department of Psychological Medicine, Institute of Psychiatry and King's College Hospital, London
*
Professor Robin Murray, Department of Psychological Medicine, Institute of Psychiatry, London SE5 8AF
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Abstract

Background

Recently, several investigators have reported an association between influenza epidemics and increased birth rates of ‘preschizophrenic’ individuals some four to six months later. Here we examine whether maternal exposure to other infectious diseases can also predispose the foetus to later schizophrenia.

Method

Two independent sets of dates of birth of first admission schizophrenic patients, born between 1938 and 1965 in England and Wales, were obtained from the Mental Health Enquiry in England and Wales. Data on the number of deaths per month from 16 infectious diseases between 1937 and 1965 in England and Wales were also collected. We used a Poisson regression model to examine the relationship between deaths from infectious diseases and schizophrenic births.

Results

In the two separate data sets, increased national deaths from bronchopneumonia preceded, by three and five months respectively, increased numbers of schizophrenic births. We did not find any other significant associations between schizophrenic births and any of the other 15 infectious diseases.

Conclusions

The association between deaths from bronchopneumonia and increased schizophrenic births some months later may be a reflection of the fact that bronchopneumonia deaths increase markedly during influenza epidemics.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 165 , Issue 3 , September 1994 , pp. 353 - 356
Copyright
Copyright © Royal College of Psychiatrists, 1994 

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