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Regional Density and Survival in Senile Dementia

An Interim Report on a Prospective Computed Tomographic Study

Published online by Cambridge University Press:  29 January 2018

John Colgan*
Affiliation:
Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF

Summary

Computed cranial tomography was performed on 48 patients with Senile Dementia of the Alzheimer Type (SDAT) who have since been followed up in a continuing prospective study. At six-months follow-up, ten patients had died; these did not differ significantly from the survivors either in mean age or duration of dementia, although the latter tended to have been shorter in the deceased. Despite having shorter histories, the deceased had performed worse on initial testing with several cognitive measures, and this was significant for the mental test score; this suggests some patients may have a more rapidly progressive form of SDAT. In a comparison between the CT scan of the deceased and survivors, the deceased were found to have significantly lower mean attenuation densities in the parietal, occipital, and left thalamic regions. The hypothesis that low attenuation density in the parietal regions of the CT scan in SDAT is associated with a more rapid demise is supported for the present period of follow-up.

Type
Papers
Copyright
Copyright © 1985 The Royal College of Psychiatrists 

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References

Bondareff, W. & Levy, R. (1981) Quantitative Computed Tomography in senile dementia. Archives of General Psychiatry, 38, 13651368.Google Scholar
Constantinidis, J. (1978) Is Alzheimer's disease a major form of senile dementia? In Alzheimer's Disease: Senile Dementia and Related Disorders, (eds. Katzman, R. & Terry, R.). New York: Raven Press.Google Scholar
Copeland, J. R. M., Kelleher, M. J., Kellett, J. M., Gourley, A. J., Gurland, B. J., Fleiss, J. L. & Sharpe, L. (1976) A semi-structured clinical interview for the assessment of diagnosis and mental state in the elderly: The Geriatric Mental State Schedule. Psychological Medicine, 6, 439449.CrossRefGoogle Scholar
de Leon, M. & George, A. (1983) C. T. in ageing and senile dementia of the Alzheimer type. In Advances in Neurology, Vol. 38, The Dementias, (eds. Mayeux, R. & Rosen, W.). New York: Raven Press.Google Scholar
Hodkinson, H. (1973) Mental impairment in the elderly. Journal of Royal College of Physicians of London, 7, 305317.Google Scholar
Jacoby, R. & Levy, R. (1980) Computed tomography in the elderly: II. Senile dementia: diagnosis and functional impairment. British Journal of Psychiatry, 136, 256269.CrossRefGoogle Scholar
Kendrick, D. (1965) Speed and learning in the diagnosis of diffuse brain damage in elderly subjects: A Bayseian statistical approach. British Journal of Social & Clinical Psychology, 4, 141148.Google Scholar
McDonald, C. (1969) Clinical heterogeneity in senile dementia. British Journal of Psychiatry, 115, 267271.Google Scholar
Naguib, M. & Levy, R. (1982a) Prediction of outcome in senile dementia—A CT Study. British Journal of Psychiatry, 140, 263267.CrossRefGoogle Scholar
Naguib, M. & Levy, R. (1982b) CT scanning in senile dementia, a follow-up of survivors. British Journal of Psychiatry, 141, 618620.CrossRefGoogle ScholarPubMed
Whitehead, A. (1976) The prediction of outcome in elderly psychiatric patients. Psychological Medicine, 6, 469479.Google Scholar
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