Hostname: page-component-cd9895bd7-gvvz8 Total loading time: 0 Render date: 2024-12-31T20:46:31.319Z Has data issue: false hasContentIssue false
  • English
  • Français

Regional Cerebral Blood Flow and Lateralized Hemispheric Dysfunction in Depression

Published online by Cambridge University Press:  29 January 2018

P. Uytdenhoef ,
P. Portelange ,
J. Jacquy ,
G. Charles ,
P. Linkowski  and
J. Mendlewicz
P. Uytdenhoef
Affiliation:
Hôpital Civil de Charleroi, 2 Boulevard Paul Janson, 6000 Charleroi, Belgium
P. Portelange
Affiliation:
Department of Isotopes, Hôpital Civil de Charleroi
J. Jacquy
Affiliation:
Department of Neurology, Hôpital Civil de Charleroi
G. Charles
Affiliation:
Hôpital Civil de Charleroi
P. Linkowski
Affiliation:
Hôpital Erasme, Free University of Brussels, 808 Route de Lennik, B-1070 Brussels
J. Mendlewicz
Affiliation:
Department of Psychiatry, Hôpital Erasme, Free University of Brussels, 808 Route de Lennik, 1070 Brussels
Get access Rights & Permissions [Opens in a new window]

Summary

Cerebral blood flow is known as an indicator of cerebral metabolism. Using the 133Xenon inhalation method, we studied the regional cerebral blood flow (r-CBF) in patients with different subtypes of depression and in remission. A left frontal hypervascularization and a right posterior hypovascularization were found in major depressives, compared to normal subjects, minor depressives, and normothymic bipolar patients. These results tend to confirm the existence of cerebral dysfunction in both hemispheres in major depression, as reported by other authors using different techniques.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 143 , Issue 2 , August 1983 , pp. 128 - 132
Copyright
Copyright © 1983 The Royal College of Psychiatrists 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

D'Elia, G. & Perris, C. (1973) Cerebral functional dominance and depression. Acta Psychiatrica Scandinavica, 49, 191–7.Google Scholar
D'Elia, G. & Perris, C. (1974) Cerebral functional dominance and memory functions: an analysis of EEG integrated amplitude in depressive psychotics. Acta Psychiatrica Scandinavica (Supplement), 143–57.Google Scholar
Flor-Henry, P. (1976) Lateralized temporal-limbic dysfunction and psychopathology. Annals of the New York Academy of Sciences, 280, 777–95.CrossRefGoogle ScholarPubMed
Gruzelier, J. & Venables, P. (1974) Bimodality and lateral asymmetry of skin conductance orienting activity in schizophrenics: replication and evidence of lateral asymmetry in patients with depression and disorders of personality. Biological Psychiatry, 8, 55–74.Google ScholarPubMed
Gruzelier, J. & Flor-Henry, P. (1979) Hemispheric asymmetries of function in psychopathology. Amsterdam: Biomedical Press.Google Scholar
Gustafson, L., Johanson, M., Risberg, J. & Silfverskiöld, P. (1981) Regional cerebral blood flow in organic dementias, affective disorders and confusional states. Third World Congress of Biological Psychiatry, Stockholm.Google Scholar
Hamilton, M. (1960) A rating scale for depression. Journal of Neurology, Neurosurgery and Psychiatry, 23, 56–62.Google Scholar
Ingvar, D. H. & Franzen, G. (1974) Abnormalities of cerebral blood flow distribution in patients with chronic schizophrenia. Acta Psychiatrica Scandinavica, 50, 425–62.Google Scholar
Ingvar, D. H. (1980) Abnormal distribution of cerebral activity in chronic schizophrenia: a neurophysiological interpretation. In Perspectives in Schizophrenia Research. (eds. Baxter, C. F. and Melnechuck, T.). New York: Raven Press.Google Scholar
Ingvar, D. H. (1981) Normal and abnormal mentation related to the cerebral circulation and metabolism. Third World Congress of Biological Psychiatry, Stockholm, 1981.Google Scholar
Jacquy, J., Wilmotte, J., Piraux, A. & Noël, G. (1976) Cerebral Blood Flow patterns studied by rhinencephalography in schizophrenia. Neuropsychobiology, 2, 94–103.Google Scholar
Kuhl, D., Metter, E. J., Riegb, W. & Phelps, M. (1982) Effects of human aging on patterns of local cerebral glucose utilization determined by the 18 F-fluorodésoxyglucose method. Journal of Cerebral Blood Flow and Metabolism, 2, 163–71.Google Scholar
Lassen, N., Roland, P. E., Larsen, B. et al (1977) Mapping of human cerebral function: a study of the regional cerebral blood flow during rest; its reproducibility and the activations seen during basic sensory and motor functions. Acta Neurologica Scandinavica, Supplement 64, 56, 262–3.Google Scholar
Mathew, R. J., Meyer, J. S., Francis, D. J., Semchuck, K. M., Mortel, K. & Claghorn, J. L. (1980) Cerebral blood flow in depression. American Journal of Psychiatry, 137, 1449–50.Google Scholar
Melamed, E., Lavy, S., Bentin, S., Cooper, G. & Rinot, Y. (1980) Reduction in regional cerebral blood flow during normal aging in man. Stroke, 11, 31–34.Google Scholar
Meyer, J. S., Ishiara, N., Deshmukh, V. D. et al (1978) Improved method for noninvasive measurement of regional cerebral blood flow by 133Xenon inhalation, Part 1, Stroke, 9, 195–204.Google Scholar
Myslobodsky, M. S. & Horesh, N. (1979) Bilateral electrodermal activity in depressive patients. Biological Psychiatry, 6, 111–20.Google Scholar
Obrist, W. D., Thomson, H. K., Want, H. S. et al (1975) Regional cerebral blood flow estimated by 133Xenon inhalation. Stroke, 6, 245–56.Google Scholar
Perris, C. & Monakhov, K. (1979) Depressive symptomatology and systemic analysis of the EEG. In Hemisphere Asymmetries of Function in Psychopathology. (eds. Gruzelier, J. and Flor-Henry, P.). Amsterdam: Biomedical Press.Google Scholar
Prohovnik, I., Håkansson, K. & Risberg, J. (1980) Observations on the functional significance of regional cerebral blood flow in “resting” normal subjects. Neuropsychologia, 18, 203–17.Google Scholar
Spitzer, R. L., Endicott, J. & Robbins, E. (1975) Research Diagnostic Criteria for a selected group of functional disorders, 2nd edition, New York: New York State Psychiatric Institute.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.