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Reduced Central Serotonergic Activity in Mania: Implications for the Relationship between Depression and Mania

Published online by Cambridge University Press:  29 January 2018

J. Mendels  and
A. Frazer
J. Mendels
Affiliation:
Veterans Administration Hospital, Philadelphia, Pa. 19104, U.S.A.
A. Frazer
Affiliation:
Veterans Administration Hospital, Philadelphia, Pa. 19104, U.S.A.
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Extract

For the past decade there has been extensive interest in the hypothesized association between brain amine function and disturbances in mood (either depression or mania). The more influential theories have postulated that clinical depression is associated with a decrease in aminergic function (either norepinephrine, dopamine or serotonin) while mania is associated with increased activity of these amines. This essentially ‘bipolar’ approach has tended to dominate most studies in this area. Evidence supporting these theories has been extensively reviewed (11, 61, 70) and need not be detailed here.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 126 , Issue 3 , March 1975 , pp. 241 - 248
Copyright
Copyright © Royal College of Psychiatrists, 1975 

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