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Rapid Response to Lithium in Phenelzine Non-responders

Published online by Cambridge University Press:  29 January 2018

J. Craig Nelson  and
Robert Byck
J. Craig Nelson
Affiliation:
Department of Psychiatry
Robert Byck
Affiliation:
Yale University School of Medicine, 333 Cedar Street, New Haven, CT065J0, USA
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Summary

Three patients suffering from major depressive disorder with melancholia and unresponsive to a three-week trial of adequate dosage of phenelzine, received lithium. Each responded within a five-day period. The similarity to lithium augmentation of tricyclic treatment is noted and discussed.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 141 , Issue 1 , July 1982 , pp. 85 - 86
Copyright
Copyright © The Royal College of Psychiatrists 

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References

Charney, D. S., Menkes, D. B. & Heninger, G. R. (1981) Receptor sensitivity and the mechanism of action of antidepressant treatment. Archives of General Psychiatry, 38, 1160–80.Google Scholar
DeMontigny, C. & Aghajanian, G. K. (1978) Tricyclic antidepressants: Long term treatment increases responsivity of rat forebrain neurons to serotonin. Science, 202, 1303–6.Google Scholar
DeMontigny, C. Grunberg, F., Maher, A. & De Schenes, J. P. (1981) Lithium induces rapid relief of depression in tricyclic anti-depressant drug non-responders. British Journal of Psychiatry, 138, 252–6.Google Scholar
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