Hostname: page-component-586b7cd67f-tf8b9 Total loading time: 0 Render date: 2024-11-22T08:24:08.965Z Has data issue: false hasContentIssue false
  • English
  • Français

Propranolol in Neurotic and Thyrotoxic Anxiety

Published online by Cambridge University Press:  29 January 2018

Ian Ramsay ,
Steven Greer  and
Christopher Bagley
Ian Ramsay
Affiliation:
Senior Lecturer, Department of Medicine, King's College Hospital Medical School; Regional Endocrine Centre, North Middlesex Hospital, London, N.18
Steven Greer
Affiliation:
Department of Psychological Medicine and Medical Unit, King's College Hospital, London, S.E.5
Christopher Bagley
Affiliation:
Centre for Social Research, University of Sussex, Falmer, Brighton
Get access Rights & Permissions [Opens in a new window]

Extract

D-L-propranolol has been reported as having a beneficial effect in anxiety (Granville-Grossman and Turner, 1966; Wheatley, 1969; Suzman, 1971). The effect is believed to be due to the drug's (β-adrenergic blocking action which suppresses many of the somatic manifestations of anxiety, such as tachycardia (Turner, Granville-Grossman and Smart, 1965) and tremor (Marsden, Gimlette, McAllister, Owen and Miller, 1968). Although the peripheral manifestations of anxiety may be ameliorated by propranolol it is not clear whether the drug has any effect on the subjective, central feelings of anxiety experienced by the patient (Marsden, 1971).

Type
Research Article
Information
The British Journal of Psychiatry , Volume 122 , Issue 570 , May 1973 , pp. 555 - 560
Copyright
Copyright © Royal College of Psychiatrists, 1973 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Bagley, C., Greer, S., and Ramsay, I. (1973). To be published.Google Scholar
Black, A. A. (1966). ‘Factors predisposing to a placebo response in new out-patients with anxiety states.’ British Journal of Psychiatry, 112, 557–67.Google Scholar
Bonn, J. A., and Turner, P. (1971). ‘D-propranolol and anxiety.’ Lancet, ii, 1355–6.Google Scholar
Cattell, R. B., and Scheier, I. H. (1963). IPAT Anxiety Scale Questionnaire. Champaign, Illinois.Google Scholar
Dewhurst, W. G., and Marley, E. (1965). ‘Action of sympathomimetic and allied admines on the C.N.S. of the chicken.’ British Journal of Pharmacology and Chemotherapy, 25, 705–27.Google Scholar
Frolich, E. D., Dunstan, H. P., and Page, I. H. (1966). ‘Hyperdynamic beta-adrenergic circulatory state.’ Archives of Internal Medicine, 117, 614–9.Google Scholar
Geddes, L. A., and Baker, L. E. (1967). ‘The specific resistance of biological material—a compendium of data for the biomedical engineer and physiologist.’ Medical and Biological Engineering, 5, 271–93.Google Scholar
Granville-Grossman, K. L., and Turner, P. (1966). ‘The effect of propranolol on anxiety.’ Lancet, ii, 788–90.Google Scholar
Greer, S., Ramsay, I., and Bagley, C. (1973). ‘Neurotic and thyrotoxic anxiety; clinical, psychological and physiological measurements.’ British Journal of Psychiatry, 122, 547–54.Google Scholar
Howitt, G., and Rowlands, D.J. (1966). ‘Beta-sympathetic blockade in hyperthyroidism.’ Lancet, i, 628–31.Google Scholar
Lader, M. H., and Wing, L. (1966). Physiological Measures, Sedative MDrugs and Morbid Anxiety. Maudsley Monograph No. 14, London.Google Scholar
Leszkovsky, G., and Tardos, L. (1965). ‘Some effects of propranolol on the central nervous system.’ Journal of Pharmacy and Pharmacology, 17, 518–9.Google Scholar
Marsden, C. D., Gimlette, T. M. D., McAllister, R. G., Owen, D. A. L., and Miller, T. N. (1968). ‘Effect of β-adrenergic blockade on finger tremor and achilles reflex time in anxious and thyrotoxic patients.’ Acta Endocrinologica, 57, 353–62.Google Scholar
Marsden, C. W. (1971). Postgraduate Medical Journal, 47, Supplement, January, p. 100.Google Scholar
Maxwell, A. E. (1961). Analysing Qualitative Data. London.Google Scholar
Shanks, R. G., Hadden, D. R., Lowe, D. C., McDevitt, D. C., and Montgomery, D. A. D. (1969). ‘Controlled trials of propranolol in thyrotoxicosis.’ Lancet, i, 993–4.Google Scholar
Sternbach, R. A. (1960). ‘Some relationships among various “dimensions” of autonomic activity.’ Psycho-somatic Medicine, 22, 430.Google Scholar
Suzman, M. M. (1971). Postgraduate Medical Journal, 47, Supplement, January, p. 104.Google Scholar
Turner, P., Granville-Grossman, K. L., and Smart, J. V. (1965). ‘Effect of adrenergic receptor blockade on the tachycardia of thyrotoxicosis and anxiety state.’ Lancet, ii, 1316–8.Google Scholar
Wheatley, D. (1969). ‘Comparative effects of propranolol and chlordiazepoxide in anxiety states.’ British Journal of Psychiatry, 115, 1411–2.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.