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Plasma Free Fatty Acids Before and After an Intravenous Insulin Injection in Acute Schizophrenic Men

Published online by Cambridge University Press:  29 January 2018

G. Franzén
G. Franzén*
Affiliation:
University of Lund, Department of Psychiatiy II, St. Lars Hospital, 220 06 Lund, Sweden
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Extract

The possibility of abnormalities in carbohydrate metabolism in schizophrenia has been stressed by many authors (Mann 1925, Freeman et al., 1943, Braceland et al., 1945, Morgan and Pilgrim 1952, Henneman et al., 1954, Moya et al., 1958, Lingjaerde and Skaug 1959). As there is a close relation between lipid metabolism (in terms of plasma free fatty acids, FFA) and glucose metabolism Mueller (1961, 1962) tested the FFA-response to insulin-induced hypoglycaemia in chronic schizophrenic patients. He found that schizophrenics showed less reduction in FFA-values than healthy controls, in some cases even an increase. Results were later presented which tend to confirm Mueller's data (van Sickle et al., 1966). Interest was focused on increased sympathetic activity in the patients, and infusion experiments with epinephrine (van Sickle et al., 1966) and norepinephrine (Cardon and Mueller 1964) were performed without producing conclusive results.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 116 , Issue 531 , February 1970 , pp. 173 - 177
Copyright
Copyright © Royal College of Psychiatrists, 1970 

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