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Plasma Folate and Affective Morbidity During Long-Term Lithium Therapy

Published online by Cambridge University Press:  29 January 2018

A. Coppen  and
M. T. Abou-Saleh
A. Coppen
Affiliation:
MRC Neuropsychiatry Research Laboratory, West Park Hospital, Epsom, Surrey KT19 8PB, England
M. T. Abou-Saleh
Affiliation:
MRC Neuropsychiatry Research Laboratory, West Park Hospital, Epsom, Surrey KT19 8PB, England
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Summary

In 107 patients on long-term lithium, those with lower plasma folate concentration had a higher affective morbidity than those with higher folate, both at the time and during the previous two years. The association was not the result of weight change or the concomitant use of other drugs. Animal work reporting a decreased synthesis of 5-HT both in folate-deficient animals and in animals fed excessive amounts of folate suggests that it may be important for lithium patients to receive folate supplements to their diet for maximum therapeutic effect.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 141 , Issue 1 , July 1982 , pp. 87 - 89
Copyright
Copyright © The Royal College of Psychiatrists 

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References

Beck, A. T., Ward, C. M., Mendelson, M., Mock, J. & Erbaugh, J. (1961) An inventory for measuring depression. Archives of General Psychiatry, 4, 561–71.CrossRefGoogle ScholarPubMed
Botez, M. I., Young, S. M., Bachevalier, J. & Gauthier, S. (1979) Folate deficiency and decreased brain 5-hydroxytryptamine synthesis in man and rat. Nature (London), 278, 182–3.Google Scholar
Carney, M. W. P. (1967) Serum folate values in 423 psychiatric patients. British Medical Journal, 4, 512–16.Google Scholar
Carney, M. W. P. & Sheffield, B. F. (1978) Serum folic acid and B12 in 272 psychiatric patients. Psychological Medicine, 8, 139–44.Google Scholar
Coppen, A. (1967) The biochemistry of affective disorders. British Journal of Psychiatry, 113, 1237–64.CrossRefGoogle ScholarPubMed
Coppen, A. Prange, A. J., Whybrow, P. C. & Noguera, R. (1972) Abnormalities of indoleamines in affective disorders. Archives of General Psychiatry, 26, 474–8.Google Scholar
Coppen, A. Peet, M., Bailey, J., Noguera, R., Burns, B. H., Swani, M. S., Maggs, R. & Gardner, R. (1973) Double-blind and open prospective studies of lithium prophylaxis in affective disorders. Psychiatria, Neurologia, Neurochirurgia (Amst.), 76, 501–10.Google Scholar
Hunter, R., Jones, M., Jones, T. G. & Matthews, D. M. (1967) Serum B12 and folate concentrations in mental patients. British Journal of Psychiatry, 113, 1291–95.Google Scholar
Hunter, R., Barnes, J., Oakley, H. F. & Matthews, D. M. (1970) Toxicity of folic acid given in pharmacological doses to healthy volunteers. Lancet, i, 61–3.Google Scholar
Reynolds, E. H., Preece, J. M., Bailey, J. & Coppen, A. (1970) Folate deficiency in depressive illness. British Journal of Psychiatry, 117, 287–92.CrossRefGoogle ScholarPubMed
Thornton, W. E. & Thornton, B. P. (1978) Folic acid, mental function and dietary habits. Journal of Clinical Psychiatry, 39, 315–22.Google Scholar
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