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Plasma and CSF Gaba in Affective Illness

Published online by Cambridge University Press:  29 January 2018

Wade H. Berrettini ,
John I. Nurnberger Jr. ,
Theodore Hare ,
Elliott S. Gershon  and
Robert M. Post
Wade H. Berrettini*
Affiliation:
Bldg. 10, Rm. 3N218, NIMH, 9000 Rockvilie Pike, Bethesda, Maryland 20205, USA
John I. Nurnberger Jr.
Affiliation:
Section on Psychogenetics, Biological Psychiatry Branch, NIMH
Theodore Hare
Affiliation:
Department of Pharmacology, Thomas Jefferson University, Philadelphia, Pennyslvania 19107
Elliott S. Gershon
Affiliation:
Biological Psychiatry Branch, NIMH
Robert M. Post
Affiliation:
Section on Psychobiology, Biological Psychiatry Branch, NIMH
*
∗Correspondence.
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Summary

CSF and plasma GABA was measured in patients with bipolar affective illness and matched controls. There was no correlation between CSF and plasma GABA in 10 pairs of simultaneously obtained samples. Plasma GABA was significantly lower in a group of 10 euthymic medication-free bipolar patients compared to 41 normal volunteers (P <.02). This finding was replicated in a second study involving 6 patients and 10 normal volunteers. Twin studies showed a high correlation between members of 11 monozygotic twin pairs (P <.008). Diurnal variation was minimal, but bimonthly sampling over one year revealed somewhat higher values in the late summer compared to late winter.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 141 , Issue 5 , November 1982 , pp. 483 - 487
Copyright
Copyright © Royal College of Psychiatrists, 1982 

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References

Balletto, E., Cherchi, M. A., Arillo, A., Doria-Lamba, L., Melodia, F. & Mensi, P. (1978) GABA synthesis in erythrocytes of Testudo hermanni Gmelin. Communications in Biochemistry and Physiology, 61, 281–2.Google ScholarPubMed
Bernasconi, R. & Martin, P. (1979) Effects of antiepileptic drugs on the GABA turnover rate. Archives of Pharmacology, 307, 251.Google Scholar
Berrettini, W. H. & Post, R. M. (1982) GABA in affective illness. In Neurobiology of Mood Disorders (ed. Post, R. M. and Ballenger, J.). Baltimore: Williams & Wilkins (in press).Google Scholar
Emrich, H. M., v. Zerssen, O., Kissling, W., Moller, H. J. & Windorfer, A. (1980) Effect of sodium valproate on mania. Archives Psychiatrica Nervenkranken, 229, 1–21.CrossRefGoogle ScholarPubMed
Ferkany, J. W., Butler, I. J. & Enna, S. J. (1979) Effect of drugs on rat brain CSF and blood GABA content. Journal of Neurochemistry, 33, 29–33.CrossRefGoogle Scholar
Ferkany, J. W., Smith, L. A., Seifert, W. E. Jr., Caprioli, R. M. & Enna, S. J. (1978) Measurement of GABA in blood. Life Sciences, 22, 2121–8.Google ScholarPubMed
Gerner, R. H. & Hare, T. A. (1981) CSF GABA in normals, depression, schizophrenia, mania and anorexia nervosa. American Journal of Psychiatry, 138, 1098–101.Google ScholarPubMed
Glaesar, B. S. & Hare, T. A. (1975) Measurement of GABA in human cerebrospinal fluid. Biochemical Medicine, 12, 274–82.Google Scholar
Gold, B. I., Bowers, M. B. Jr., Roth, R. H. & Sweeney, D. W. (1980) GABA levels in CSF of patients with psychiatric disorders. American Journal of Psychiatry, 137, 362–4.Google ScholarPubMed
Green, A. R., Peralta, E., Hong, J. S., Mao, C. C., Atterwill, C. K. & Costa, E. (1978) Alterations in GABA metabolism and met-enkephalin content in rat brain following repeated electroconvulsive shocks. Journal of Neurochemistry, 31, 607–18.CrossRefGoogle ScholarPubMed
Grossman, N. H., Hare, T. A., Manyam, M. V. B., Glaesar, B. S. & Wood, J. H. (1980) Stability of GABA levels in CSF under various conditions of storage. Brain Research, 182, 99.CrossRefGoogle ScholarPubMed
Hare, T. A. & Manyam, N. V. B. (1980) Rapid and sensitive ion-exchange fluorometric measurement of GABA in physiologic fluids. Analytical Biochemistry, 101, 349–55.CrossRefGoogle Scholar
Kuriyama, K. & Sze, P. Y. (1970) Penetration of GABA across the blood-brain barrier. Pharmacologist, 13, 207–12.Google Scholar
Loscher, W. (1979) GABA in plasma and CSF of different species. Effects of γ-acetylenic GABA, γ-vinyl GABA and sodium valproate. Journal of Neurochemistry, 32, 1587–91.CrossRefGoogle Scholar
Loscher, W. & Schmidt, D. (1981) Plasma GABA levels in neurological patients under treatment with valproic acid. Life Sciences, 28, 2383–8.CrossRefGoogle ScholarPubMed
Maggi, A. & Enna, S. J. (1980) Regional alterations in rat brain neurotransmitter systems following chronic lithium treatment. Journal of Neurochemistry, 34, 888–92.CrossRefGoogle ScholarPubMed
Manyam, N. V. B., Hare, T. A. & Katz, Z. (1980) Effect of isoniazid on CSF and plasma GABA levels in Huntington's Disease. Life Sciences, 26, 1303–8.CrossRefGoogle Scholar
Mazure, C. & Gershon, E. S. (1979) Blindness and reliability in lifetime psychiatric diagnosis. Archives of General Psychiatry, 127, 1–10.Google Scholar
Morselli, P. L., Bossi, L., Henry, J. F., Zarifian, E. & Bartholini, G. (1980) On the therapeutic action of SL 76 002, a new GABA-mimetic agent. Brain Research Bulletin, 5 (Supplement), 411–15.CrossRefGoogle Scholar
Nakamura, S., Miyata, S. & Kameyama, M. (1978) Serum DBH, GAD and serum amino acid decarboxylase in involuntary movement disorders. Rinsho Shinkeigaku, 19, 511–14.Google Scholar
Petty, F. & Schlesser, M. A. (1981) Plasma GABA in affective illness. Journal of Affective Disorders, 3, 334–43.CrossRefGoogle ScholarPubMed
Sherman, A. D. & Petty, F. (1980) Neurochemical basis of the action of antidepressants on learned helplessness. Behavioral and Neural Biology, 30, 119–34.CrossRefGoogle ScholarPubMed
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