Hostname: page-component-78c5997874-8bhkd Total loading time: 0 Render date: 2024-11-17T19:12:04.017Z Has data issue: false hasContentIssue false
  • English
  • Français

Plasma Amino Acid Levels in Huntington's Chorea

Published online by Cambridge University Press:  29 January 2018

J. A. G. Watt  and
W. L. Cunningham
J. A. G. Watt
Affiliation:
Gartnavel Royal Hospital, Glasgow; University of Dundee
W. L. Cunningham
Affiliation:
Queen's University, Kingston, Ontario; Heriot-Watt University, Edinburgh
Get access Rights & Permissions [Opens in a new window]

Summary

Concentrations of plasma amino acids in nine patients with Huntington's chorea and nine control patients were studied while diet and drug therapy were controlled. Significantly low values for threonine, alanine, isoleucine, leucine, lysine and histidine were found in the Huntington's chorea patients. However, since different investigators have failed to establish a consistent pattern of abnormality, it is considered that the findings are probably due to non-specific factors.

Type
Papers
Information
The British Journal of Psychiatry , Volume 132 , Issue 4 , April 1978 , pp. 394 - 397
Copyright
Copyright © Royal College of Psychiatrists, 1978 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Ackerman, P. G. & Kheim, T. (1964) Plasma amino acids in young and older adult human subjects. Clinical Chemistry, 10, 32–40.Google Scholar
Bruyn, G. W. (1966) Biochemical studies in Huntington's chorea. Part 3. Amino acids in serum and urine. Psychiatria, Neurologia, Neurochirurgia, 69, 139–42.Google Scholar
Fisher, R., Norris, J. W. & Gilka, L. (1974) GABA in Huntington's chorea. Lancet, i, 506.Google Scholar
Oepen, H. & Oepen, I. (1965) Blood amino acids in Huntington's chorea. Humangenetik, 1, 299–302.Google Scholar
Ottosson, J.-O. & Rapp, W. (1971) Serum levels of phenylalanine and tyrosine in Huntington's chorea. Acta Psychiatrica Scandinavica, Supplement 221, 89–102.Google Scholar
Perry, T. L., Hansen, S., Diamond, S. & Stedman, D. (1969) Plasma amino acid levels in Huntington's chorea. Lancet, i, 806–8.Google Scholar
Perry, T. L., Hansen, S. & Lesk, L. (1972) Plasma amino acid levels in children of patients with Huntington's chorea. Neurology, 22, 68–70.Google Scholar
Phillipson, O. T. & Bird, E. D. (1976) Plasma growth hormone concentration in Huntington's chorea. Clinical Science and Molecular Medicine, 50, 551–4.Google Scholar
Phillipson, O. T. & Bird, E. D. (1977) Plasma glucose, non-esterified fatty acids and amino acids in Huntington's chorea. Clinical Science and Molecular Medicine, 52, 311–18.Google Scholar
Podolsky, S. & Leopold, N. A. (1974) Growth hormone abnormalities in Huntington's chorea—effect of L-DOPA administration. Journal of Clinical Endocrinology and Metabolism, 39, 36–9.Google Scholar
Podolsky, S. & Leopold, N. A. (1977) Abnormal glucose tolerance and arginine tolerance tests in Huntington's disease. Gerontology, 23, 55–63.Google Scholar
Spackman, D., Stein, W. & Moore, S. (1958) Automatic recording apparatus for use in the chromatography of amino acids. Analytical Chemistry, 30, 1190–206.Google Scholar
Wehr, R. F. & Lewis, G. T. (1966) Amino acids in blood plasma of young and aged adults. Proceedings of the Society of Experimental Biology and Medicine, 121, 349–51.Google Scholar
Yates, C. M., Magill, B. E. A., Davidson, D., Murray, L. G., Wilson, H. & Pullar, I. A. (1973) Lysosomal enzymes, amino acids and acid metabolites of amines in Huntington's chorea. Clinica Chimica Acta, 44, 139–45.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.