Hostname: page-component-cd9895bd7-hc48f Total loading time: 0 Render date: 2024-12-22T16:48:32.744Z Has data issue: false hasContentIssue false
  • English
  • Français

A Pilot Study of Schizophrenia-Like Psychosis in Epilepsy Using Single-Photon Emission Computerised Tomography

Published online by Cambridge University Press:  02 January 2018

E. Jane Marshall ,
G. M. S. Syed ,
P. B. C. Fenwick  and
W. A. Lishman
E. Jane Marshall*
Affiliation:
Sections of Genetics and Neuropsychiatry, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, and Epilepsy Unit and Neuropsychiatry, Maudsley Hospital, Denmark Hill, London SE5 8AZ
G. M. S. Syed
Affiliation:
Department of Nuclear Medicine, King's College Hospital, Denmark Hill, London SE5
P. B. C. Fenwick
Affiliation:
Institute of Psychiatry, De Crespigny Park, London SE5 8AF, and Maudsley Hospital, Denmark Hill, London SE5 8AZ
W. A. Lishman
Affiliation:
Institute of Psychiatry, De Crespigny Park, London SE5 8AF, and Maudsley Hospital, Denmark Hill, London SE5 8AZ
*
∗Correspondence
Get access Rights & Permissions [Opens in a new window]

Abstract

In a pilot study, SPECT was used to explore differences in rCBF between a group of patients with schizophrenia-like psychoses of epilepsy (SLPE) and a matched group of epileptic controls. Five patients in each group were investigated and those with SLPE showed significant reductions in the index of rCBF in the left medial temporal region. These differences are being investigated further.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 163 , Issue 1 , July 1993 , pp. 32 - 36
Copyright
Copyright © The Royal College of Psychiatrists 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Annett, M. (1970) A classification of hand preference by association analysis. British Journal of Psychology, 61, 303–321.CrossRefGoogle ScholarPubMed
Bajc, M., Medved, V. & Basic, M. (1989) Cerebral perfusion in-homogenicities in schizophrenia demonstrated with single photon emission tomography and Tc-99m HMPAO. Acta Psychiatrica Scandinavica, 80, 427–433.Google Scholar
Conlon, P., Trimble, M. R. & Rogers, D. (1990) A study of epileptic psychosis using magnetic resonance imaging. British Journal of Psychiatry, 156, 231–235.Google Scholar
Crow, T. J. (1991) Temporal lobe asymmetries as the key to the etiology of schizophrenia. Schizophrenia Bulletin, 16, 433–443.Google Scholar
Engel, J. (1984) The use of positron emission tomographic scanning in epilepsy. Annals of Neurology, 15 (suppl.), 180–191.Google Scholar
Flor-Henry, P. (1969) Psychosis and temporal lobe epilepsy: a controlled investigation. Epilepsia, 10, 363–395.Google Scholar
Friston, K. J., Frith, C. D., Liddle, P. F., et al (1991) Comparing functional (PET) images: the assessment of significant change. Journal of Cerebral Blood Flow and Metabolism, 11, 690–699.Google Scholar
Gallhofer, B., Trimble, M. R., Frackowlak, R., et al (1985) A study of cerebral blood flow and metabolism in epileptic psychosis using positron emission tomography and oxygen. Journal of Neurology, Neurosurgery and Psychiatry, 48, 201–206.Google Scholar
Hill, D. (1953) Psychiatric disorders of epilepsy. Medical Press, 229, 473–475.Google Scholar
Jensen, I. & Larsen, J. K. (1979) Psychoses in drug resistant temporal lobe epilepsy. Journal of Neurology, Neurosurgery and Psychiatry, 42, 948–954.Google Scholar
Kristensen, O. & Sindrup, E. H. (1978) Psychomotor epilepsy and psychosis. Acta Neurologica Scandinavica, 57, 361–379.Google Scholar
Lassen, N. A., Andersen, A. R., Friberg, L., et al (1988) The retention of Tc-99m d-l hexa methyl propylene amine oxime in the human brain after intracarotid injection: a kinetic analysis. Journal of Cerebral Blood Flow and Metabolism, 85, 1–21.Google Scholar
Lewis, S. W., Ford, R. A., Syed, G. M., et al (1992) A controlled study of 99mTc-HMPAO single photon emission imaging in chronic schizophrenia. Psychological Medicine, 22, 27–35.CrossRefGoogle ScholarPubMed
Liddle, P. F., Friston, K. J., Frith, C. D., et al (1992) Patterns of cerebral blood flow in schizophrenia. British Journal of Psychiatry, 160, 179–186.CrossRefGoogle ScholarPubMed
Montaldi, D., Brooks, D. N., McColl, J. H., et al (1990) Measurements of regional cerebral blood flow and cognitive performance in Alzheimer's disease. Journal of Neurology, Neurosurgery and Psychiatry, 53, 33–38.Google Scholar
Perez, M. M. & Trimble, M. R. (1980) Epileptic psychosis-diagnostic comparison with process schizophrenia. British Journal of Psychiatry, 137, 245–249.Google Scholar
Perez, M. M. & Trimble, M. R. Murray, N. M. F., et al (1985) Epileptic psychosis: an evaluation of PSE profiles. British Journal of Psychiatry, 146, 155–163.Google Scholar
Pond, D. A. (1957) Psychiatric aspects of epilepsy. Journal of the Indian Medical Profession, 3, 1441–1451.Google Scholar
Roberts, G. W., Done, D. J., Bruton, C., et al (1990) A ‘mock-up’ of schizophrenia: temporal lobe epilepsy and schizophrenia-like psychosis. Biological Psychiatry, 28, 127–143.Google Scholar
Sharp, F. P., Smith, F. W., Gemmell, H. G., et al (1986) Technitium-99m HMPAO stereoisomers as potential agents for imaging the regional cerebral blood flow: human volunteer studies. Journal of Nuclear Medicine, 27, 171–177.Google Scholar
Sherwin, I. (1981) Psychosis associated with epilepsy: significance of the laterality of the epileptogenic lesion. Journal of Neurology, Neurosurgery and Psychiatry, 44, 83–85.Google Scholar
Slater, E., Beard, A. W. & Glithero, E. (1963) The schizophrenialike psychoses of epilepsy. British Journal of Psychiatry, 109, 95–150.Google Scholar
Spitzer, R. L. & Endicott, J. (1978) Schedule of Affective Disorders and Schizophrenia-Lifetime Version. New York: State Psychiatric Institute, Biometrics Research.Google Scholar
Spitzer, R. L. Endicott, J. & Robins, E. (1978) Research Diagnostic Criteria: rationale and reliability. Archives of General Psychiatry, 35, 773–782.Google Scholar
Taylor, D. (1975) Factors influencing the occurrence of schizophrenia-like psychosis in patients with temporal lobe epilepsy. Psychological Medicine, 5, 249–254.Google Scholar
Toone, B. K., Dawson, J. & Driver, M. V. (1982) Psychoses of epilepsy: a radiological evaluation. British Journal of Psychiatry, 140, 244–248.Google Scholar
Trimble, M. R. (1991) The Psychoses of Epilepsy. New York: Raven Press.Google Scholar
Wechsler, D. (1981) WAIS-R Manual. New York: Psychological Corporation.Google Scholar
Wing, J. K., Cooper, J. E. & Sartorius, N. (1974) The Measurement and Classification of Psychiatric Symptoms. Cambridge: Cambridge University Press.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.