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People at risk of schizophrenia

Sample characteristics of the first 100 cases in the Edinburgh High-Risk Study

Published online by Cambridge University Press:  03 January 2018

Ann Hodges ,
Majella Byrne ,
Elizabeth Grant  and
Eve Johnstone
Ann Hodges
Affiliation:
Department of Psychiatry, University of Edinburgh, Edinburgh
Majella Byrne
Affiliation:
Department of Psychiatry, University of Edinburgh, Edinburgh
Elizabeth Grant
Affiliation:
Department of Psychiatry, University of Edinburgh, Edinburgh
Eve Johnstone*
Affiliation:
Department of Psychiatry, University of Edinburgh, Edinburgh
*
Eve Johnstone, Department of Psychiatry, University of Edinburgh, Morningside Park, Edinburgh EHIO 5HF
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Abstract

Background

The Edinburgh High-Risk Study is designed to explore the underlying pathogenesis of schizophrenia.

Aims

To establish the sample characteristics of the first 100 subjects in this study of young adults at risk of schizophrenia for genetic reasons, and to compare them with appropriate controls.

Method

Details of the recruitment of the first 100 high-risk subjects aged 16–25 years into a prospective Scotland-wide study are given. Subjects and 30 age- and gender-matched normal controls were interviewed using the PSE, SADS-L and SIS and an unstructured psychiatric interview.

Results

Some significant differences emerged between the high-risk group and the control group, namely in previous psychiatric history (31 v. 6.3%), forensic contacts (19 v. 3.1%) and delinquent behaviour (20 v. 3.1%). There were also differences in some parameters from the SIS: childhood social isolation, interpersonal sensitivity, social isolation, suicidal ideation, restricted affect, oddness and disordered speech.

Conclusions

These differences may represent increased risk of developing schizophrenia although their true significance will not be revealed until the cohort has been followed through the at-risk years.

Type
Preliminary Report
Information
The British Journal of Psychiatry , Volume 174 , Issue 6 , June 1999 , pp. 547 - 553
Copyright
Copyright © 1999 The Royal College of Psychiatrists 

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Footnotes

†

See invited commentaries pp. 554–557. this issue.

Declaration of interest

Supported by the Medical Research Council.

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