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Obstetric Complications, the Putative Familial-Sporadic Distinction, and Tardive Dyskinesia in Schizophrenia

Published online by Cambridge University Press:  02 January 2018

Eadbhard O'Callaghan ,
Conall Larkin ,
Anthony Kinsella  and
John L. Waddington
Eadbhard O'Callaghan
Affiliation:
Cluain Mhuire Family Centre, Co. Dublin, St Stephen's Green, Dublin 2, Ireland
Conall Larkin
Affiliation:
Cluain Mhuire Family Centre, Co. Dublin, St Stephen's Green, Dublin 2, Ireland
Anthony Kinsella
Affiliation:
Dublin Institute of Technology, St Stephen's Green, Dublin 2, Ireland
John L. Waddington*
Affiliation:
Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, St Stephen's Green, Dublin 2, Ireland
*
∗Correspondence
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Abstract

Obstetric complications were more common in the histories of those schizophrenic outpatients without a family history of psychiatric disorder, and were associated with an earlier onset of their illness. Those patients with tardive dyskinesia were more likely to have a family history of psychiatric disorder, less likely to have experienced obstetric complications, and showed greater cognitive deficit. Obstetric complications should be considered in juxtaposition with genetic factors in evaluating the putative familial-sporadic distinction in schizophrenia. Additionally, familial/genetic factors appear to contribute to vulnerability to tardive dyskinesia.

Type
Papers
Information
The British Journal of Psychiatry , Volume 157 , Issue 4 , October 1990 , pp. 578 - 584
Copyright
Copyright © Royal College of Psychiatrists, 1990 

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References

American Psychiatric Association (1980) Diagnostic and Statistical Manual of Mental Disorders (3rd edn). Washington, DC: APA.Google Scholar
Andreasen, N. C., Endicott, J., Spitzer, R., et al (1977) The family history method using diagnostic criteria. Archives of General Psychiatry, 34, 1229–1235.CrossRefGoogle ScholarPubMed
Andreasen, N. C., Rice, J., Endicott, J., et al (1986) The family history approach to diagnosis: how useful is it? Archives of General Psychiatry, 43, 421–429.Google Scholar
Asarnow, R. T., Cromwell, R. L. & Rennick, P. M. (1978) Cognitive and evoked response measures of information processing in schizophrenics with and without a family history of schizophrenia. Journal of Nervous and Mental Disease, 166, 719–730.Google Scholar
Baker, N. J., Berry, S. L. & Adler, L. E. (1987) Family diagnoses missed on a clinical inpatient service. American Journal of Psychiatry, 144, 630–632.Google ScholarPubMed
Bartels, M., Mann, K. & Friedrich, W. (1985) Tardive dyskinesia: marked predominance of non-genetic schizophrenia. Biological Psychiatry, 20, 101–103.Google Scholar
Cohen, J. (1960) A coefficient of agreement for nominal scales. Educational and Psychological Measurement, 20, 37–46.Google Scholar
Dixon, W. J. (1983) BMDP Statistical Software. Berkeley: University of California Press.Google Scholar
Eaves, L. J., Kendler, K. S. & Schulz, S. C. (1986) The familial-sporadic classification: its power for the resolution of genetic and environmental etiologic factors. Journal of Psychiatric Research, 20, 115–130.Google Scholar
Ernst, C. & Angst, J. (1983) Birth Order. Berlin: Springer Verlag.Google Scholar
Fish, B. (1977) Neurobiologic antecedents of schizophrenia in children: evidence for an inherited, congenital neurointegrative defect. Archives of General Psychiatry, 34, 1297–1313.Google Scholar
Fish, B. (1987) Infant predictors of the longitudinal course of schizophrenic development. Schizophrenia Bulletin, 13, 395–409.Google Scholar
Fleiss, J. L., Williams, J. B. W. & Dubro, A. F. (1986) Logistic regression analysis of psychiatric data. Journal of Psychiatric Research, 20, 195–209.Google Scholar
Goldin, L. R., DeLisi, L. E. & Gershon, E. S. (1987) Unravelling the relationship between genetic and environmental risk factors in psychiatric disorders. British Journal of Psychiatry, 151, 302–305.Google Scholar
Kendler, K. S., Tsuano, M. T. & Hays, P. (1987) Age at onset in schizophrenia: a familial perspective. Archives of General Psychiatry, 44, 881–890.CrossRefGoogle ScholarPubMed
Kinney, D. K., Woods, B. T. & Yurgelun-Todd, D. (1986) Neurologic abnormalities in schizophrenic patients and their families. II. Neurological and psychiatric findings in relatives. Archives of General Psychiatry, 43, 665–668.Google Scholar
Lewis, S. W. & Murray, R. M. (1987) Obstetric complications, neurodevelopmental deviance and risk of schizophrenia. Journal of Psychiatric Research, 21, 413–422.Google Scholar
Lewis, S. W., Reveley, A. M., Reveley, M. A., et al (1987) The familial/sporadic distinction as a strategy in schizophrenia research. British Journal of Psychiatry, 151, 306–313.Google Scholar
Lewis, S. W., Owen, M. J. & Murray, R. M. (1989) Obstetric complications and schizophrenia: methodology and mechanisms. In Schizophrenia: Scientific Progress (eds S. C. Schulz & C. A. Tamminga). New York: Oxford University Press.Google Scholar
McGuffin, P., Farmer, A. & Gottesman, I. I. (1987) Is there really a split in schizophrenia: the genetic evidence. British Journal of Psychiatry, 150, 581–592.Google Scholar
McNeil, T. F. (1987) Perinatal influences in the development of schizophrenia. In Biological Perspectives of Schizophrenia (eds H. Helmchen & F. A. Henn). Bristol: John Wiley.Google Scholar
McNeil, T. F. & Kaij, L. (1978) Obstetric factors in the development of schizophrenia. In The Nature of Schizophrenia (eds L. C. Wynne, R. L. Cromwell & S. Matthysse). New York: John Wiley.Google Scholar
Murray, R. M. & Lewis, S. W. (1987) Is schizophrenia a neurodevelopmental disorder? British Medical Journal, 295, 681–682.Google Scholar
National Institute of Mental Health (1976) Abnormal Involuntary Movement Scale (AIMS). In ECDEU Assessment Manual (ed W. Guy). Rockville: US Department of Health, Education & Welfare.Google Scholar
Nimgaonkar, V. L., Wessely, S. & Murray, R. M. (1988) Prevalence of familiality, obstetric complications, and structural brain damage in schizophrenic patients. British Journal of Psychiatry, 153, 191–197.CrossRefGoogle ScholarPubMed
O'Callaghan, E., Larkin, C., Redmond, O., et al (1988) ‘Early onset schizophrenia’ after teenage head injury: a case report with magnetic resonance imaging. British Journal of Psychiatry, 153, 394–396.Google Scholar
O'Callaghan, E., Larkin, C. & Waddington, J. L. (1990) Obstetric complications in schizophrenia and the validity of maternal recall. Psychological Medicine, 20, 89–94.Google Scholar
Orzack, M. H. & Kornetsky, C. (1971) Environmental and familial predictors of attentional behaviour in chronic schizophrenics. Journal of Psychiatric Research, 9, 21–29.Google Scholar
Owen, M. J., Lewis, S. W. & Murray, R. M. (1988) Obstetric complications and schizophrenia: a computed tomographic study. Psychological Medicine, 18, 331–339.Google Scholar
Parnas, J., Schulsinger, F., Teasdale, T. W., et al (1982) Perinatal complications and clinical outcome within the schizophrenia spectrum. British Journal of Psychiatry, 140, 416–420.Google Scholar
Reitan, R. M. (1958) Validity of the trail making test as an indicator of organic brain dysfunction. Perceptual and Motor Skills, 8, 271–276.CrossRefGoogle Scholar
Schooler, N. R. & Kane, J. M. (1982) Research diagnoses for tardive dyskinesia. Archives of General Psychiatry, 39, 486–487.Google Scholar
Waddington, J. L. (1987) Tardive dyskinesia in schizophrenia and other disorders: associations with ageing, cognitive dysfunction and structural brain pathology in relation to neuroleptic exposure. Human Psychopharmacology, 2, 11–22.Google Scholar
Waddington, J. L. (1988) The ageing brain, neuroleptic drugs and the enigma of schizophrenia. Irish Journal of Medical Science, 157, 135–141.Google Scholar
Waddington, J. L. & Youssef, H. A. (1987) Is schizophrenia a neurodevelopmental disorder? British Medical Journal, 295, 997–998.Google Scholar
Waddington, J. L. & Youssef, H. A. (1988) The expression of schizophrenia, affective disorder, and vulnerability to tardive dyskinesia in an extensive pedigree. British Journal of Psychiatry, 153, 376–381.CrossRefGoogle Scholar
Waddington, J. L., Youssef, H. A., Dolphin, C., et al (1987) Cognitive dysfunction, negative symptoms and tardive dyskinesia in schizophrenia: their association in relation to topography of involuntary movements and criterion of their abnormality. Archives of General Psychiatry, 44, 907–912.Google Scholar
Walker, E. & Shaye, J. (1982) Familial schizophrenia: a predictor of neuromotor and attentional abnormalities in schizophrenia. Archives of General Psychiatry, 39, 1153–1156.CrossRefGoogle ScholarPubMed
Wegner, J. T., Catalano, F., Gibraltar, J., et al (1985) Schizophrenics with tardive dyskinesia: neuropsychological deficit and family psychopathology. Archives of General Psychiatry; 42, 860–865.Google Scholar
Weinberger, D. R. (1987) Implications of normal brain development for the pathogenesis of schizophrenia. Archives of General Psychiatry, 44, 660–669.CrossRefGoogle ScholarPubMed
Weinhold, P., Wegner, J. T. & Kane, J. M. (1981) Familial occurrence of tardive dyskinesia. Journal of Clinical Psychiatry, 42, 165–166.Google Scholar
Yassa, R. & Ananth, J. (1981) Familial tardive dyskinesia. American Journal of Psychiatry, 138, 1618–1619.Google Scholar
Youssef, H. A. & Waddington, J. L. (1988a) Primitive (developmental) reflexes and diffuse cerebral dysfunction in schizophrenia and bipolar affective disorder: overrepresentation in patients with tardive dyskinesia. Biological Psychiatry, 23, 791–796.Google Scholar
Youssef, H. A. & Waddington, J. L. (1988b) Involuntary orofacial movements in hospitalised patients with mental handicap or epilepsy: relationship to developmental/intellectual deficit and presence or absence of long-term exposure to neuroleptics. Journal of Neurology, Neurosurgery and Psychiatry, 51, 863–865.Google Scholar
Zec, R. F. & Weinberger, D. R. (1986) Relationship between CT scan findings and neuropsychological performance in chronic schizophrenia. Psychiatric Clinics of North America, 9, 49–61.Google Scholar
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