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Observations on the Blood Concentration of Thyrotrophic Hormone (T.S.H.) in Schizophrenia and the Affective States

Published online by Cambridge University Press:  29 January 2018

K. E. Dewhurst ,
D. J. El Kabir ,
G. W. Harris  and
B. M. Mandelbrote
K. E. Dewhurst
Affiliation:
Littlemore Hospital, Oxford
D. J. El Kabir
Affiliation:
M.R.C. Unit of Neuroendocrinology, Oxford
G. W. Harris
Affiliation:
Oxford University; M.R.C. Unit of Neuroendocrinology
B. M. Mandelbrote
Affiliation:
Littlemore Hospital, Oxford, University of Oxford
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Extract

In a recent review (Dewhurst, El Kabir, Harris and Mandelbrote, 1968) the evidence relating the effect of stress to thyroid function has been surveyed. In that account the comment was made that although it is impossible to assess or quantify the psychological trauma that any mentally ill patient is undergoing, it would seem reasonable to assume that if emotional stress is associated with abnormal thyroid activity, then a study of thyroid function in mentally ill patients would reveal such abnormal activity. In the present work a study has been made of the function of the pituitary–thyroid axis in control subjects and in patients suffering from schizophrenia and affective illnesses. Since there is strong evidence that emotional stress in many cases affects endocrine function through the mediation of the hypothalamus and anterior pituitary gland, measurement of the blood concentration of thyrotrophic hormone (T.S.H.) has been used in the present investigation. A further reason for assaying the blood concentration of T.S.H. is that measurement of many of the more direct parameters of thyroid function are subject to variables which are difficult to control. Studies of the blood level of T.S.H. in psychiatric patients have not, so far as we know, been carried out previously.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 115 , Issue 526 , September 1969 , pp. 1003 - 1011
Copyright
Copyright © Royal College of Psychiatrists, 1969 

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References

Adams, D. D. (1965). “Pathogenesis of the hyperthyroidism of Graves' disease.” Brit. med. J., i, 1015–1019.Google Scholar
Bakke, J. L., Lawrence, N., Arnett, F., and MacFadden, W. (1961). “The fractionation of exogenous and endogenous thyroid-stimulating hormone from human and rat plasma and tissues.” J. clin. Endocr., 21, 1280–1289.Google Scholar
Bates, R. (1963). “The chick method of thyrotropin assay.” In: Thyrotropin (ed. Werner, S. C.). Pp. 290–296. Springfield, Illinois: C. C. Thomas.Google Scholar
Board, F., Persky, H., and Hamburg, D. (1956). “Psychological stress and endocrine functions.” Psychosom. Med., 18, 324–333.Google Scholar
Board, F., Wadeson, R., and Persky, H. (1957). “Depressive affect and endocrine functions.” Arch. Neurol. Psychiat., 78, 612–620.Google Scholar
Bonati, B., Salvi, A., Rancati, G. B., and Pedrelli, M. (1955). “Psicosi e tiroide. Comportamento della jodoprotidemia e colesterolemia nei malati di mente e loro modificazioni dopo elettroshock, coma insulinico, leucotomia prefrontale ed ipnoterapia.” Folia endocrinologica, 8, 321–342.Google Scholar
Bowman, K. M., Miller, E. R., Dailey, M. E., Simon, A., and Mayer, B. F. (1950). “Thyroid function in mental disease.” J. nerv. ment. Dis., 112, 404–424.Google Scholar
Bottari, P. M. (1960). “Blood concentration of thyrotrophic hormone in normals and in patients with thyroid disease.” Ciba Found. Colloq. Endocr., 13, 275–294.Google Scholar
Bottari, P. M., Donovan, B. T., and El Kabir, D. J. (1963) “A sensitive in vitro method for the assay of thyrotrophic hormone.” J. Physiol., 169, 278–291.CrossRefGoogle Scholar
D'Angelo, S. A., Paschkis, K. E., Gordon, A. S., and Cantarow, A. (1951). “Thyroid thyrotropic hormone balance in the blood of normal and endocrinopathic individuals.” J. clin. Endocr., 11, 1237–1253.Google Scholar
Desbarats-Schönbaum, M. L., Sellers, E. A., Belzile, A., and Schönbaum, E. (1967). “Some observations on a sensitive bioassay for thyrotrophin. Application to normal, hyper- and hypothyroid human serum.” Acta. endocr., Copenh., 54, 282–294.Google Scholar
Dewhurst, K. E., El Kabir, D. J., Harris, G. W., and Mandelbrote, B. M. (1968). “A review of the effect of stress on thyroid function in animals and man.” Confin. neurol., 30, 161–196.Google Scholar
El Kabir, D. J. (1960). “The estimation of thyrotrophic hormone in blood.” Abstr. Med. (Internat. Congr. Series). No. 26, 39.Google Scholar
El Kabir, D. J. (1961). “The estimation of thyrotrophic hormone in blood by a sensitive in vitro method.” In: Advances in Thyroid Research (ed. Pitt-Rivers, R. V.). Pp. 201–204. London: Pergamon Press.Google Scholar
El Kabir, D. J. (1963). “The in vitro assay of thyrotrophin.” In: Thyrotrophin (ed. Werner, S. C.). Pp. 253–257. Springfield, Illinois: C. C. Thomas.Google Scholar
El Kabir, D. J., Benhamou-Glyn, N., Doniach, D., and Roitt, I. M. (1966). “Absorption of thyroid-stimulating globulin from thyrotoxic sera by organ homogenates.” Nature, Lond., 210, 319–321.CrossRefGoogle Scholar
El Kabir, D. J., Doniach, D., and Turner-Warwick, R. T. (1963). “The serum content of thyrotrophic hormone in human thyroiditis. Low T.S.H. levels with high radioiodine uptake in mild autoimmune thyroiditis.” J. clin. Endocr., 23, 510–520.Google Scholar
Gilliland, I. C., and Strudwick, J. I. (1956). “Clinical application of an assay of thyroid-stimulating hormone in relation to exophthalmos.” Brit. med. J., i, 378–381.Google Scholar
Good, B. F. (1965). Ph.D. Thesis, University of Adelaide.Google Scholar
Harrison, T. S., Silver, D. M., and Zuidema, G. D. (1966). “Thyroid and adrenal medullary function in chronic ‘executive’ monkeys.” Endocrinology, 78, 685–689.Google Scholar
Hockaday, T. D. R., and El Kabir, D. J. “Pituitary enlargement in primary hypothyroidism of adult onset.” J. clin. Endocr., in press.Google Scholar
Kirkham, K. E. (1962). “A new bioassay technique for the measurement in vitro of thyrotrophic hormone in serum and in pituitary extracts.” J. Endocr., 25, 259–269.CrossRefGoogle Scholar
Lemarchand-Béraud, T., and Vanotti, A. (1965). “A radio immunoassay for the determination of thyroid stimulating hormone.” Experientia, 21, 353–356.Google Scholar
McKenzie, J. M. (1958). “The bioassay of thyrotropin in serum.” Endocrinology, 63, 372–382.Google Scholar
Mason, J. W., Brady, J. V., Tolson, W. W., Robinson, J. A., Taylor, E. D., and Mougey, E. H. (1961). “Patterns of thyroid, gonadal and adrenal hormone secretion related to psychological stress in the monkey.” Psychosom. Med., 23, 446.Google Scholar
Odell, W. D., Wilbur, J. F., and Paul, W. E. (1965). “Radioimmunoassay of thyrotropin in human serum.” J. clin. Endocr., 25, 1179–1188.Google Scholar
Purves, H. D., and Adams, D. D. (1960). “Thyroid stimulating hormone.” Brit. med. Bull., 16, 128–132.Google Scholar
Reichlin, S. (1959). “Peripheral thyroxine metabolism in patients with psychiatric and neurological disease.” A.M.A. Arch. gen. Psych., 1, 104–110.Google Scholar
Reiss, M., Hemphill, R. E., Maggs, R., Smith, S., Haigh, C. P., and Reiss, J. M. (1951). “Thyroid activity in mental patients.” Brit. med. J., i, 1181–1183.Google Scholar
Simpson, G. M., and Cooper, T. B. (1966). “Thyroid indices in chronic schizophrenia. III.” J. nerv. ment. Dis., 142, 58–62.Google Scholar
Simpson, G. M., Cranswick, E. H., and Blair, J. H. (1963). “Thyroid indices in chronic schizophrenia. I.” J. nerv. ment. Dis., 137, 582–590.Google Scholar
Simpson, G. M., Cranswick, E. H., and Blair, J. H. (1964). “Thyroid indices in chronic schizophrenia. II.” J. nerv. ment. Dis., 138, 581–585.Google Scholar
Utiger, R. D. (1965). “Immunoassay of human plasma T.S.H.” In: Current Topics in Thyroid Research (eds. Cassano, C. and Andreoli, M.). Pp. 513–526. New York and London: Academic Press, Inc.Google Scholar
Yamazaki, E., Noguchi, A., Sato, S., and Slingerland, D. W. (1961). “Thyrotropic activity in the serum of euthyroid, treated hyperthyroid and postoperative hypothyroid patients.” J. clin. Endocr., 21, 1127–1138.Google Scholar
Zuckerman, M., Persky, H., Hopkins, T. R., Murtaugh, T., Basu, G. K., and Schilling, M. (1966). “Comparison of stress effects of perceptual and social isolation.” Arch. gen. Psych., 14, 358–365.Google Scholar
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