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A neuropsychological perspective on three schizophrenic patients with midline structural defects

Published online by Cambridge University Press:  03 January 2018

N. M. J. Edelstyn ,
F. Oyebode ,
M. J. Riddoch ,
R. Soppitt ,
H. Moselhy  and
M. George
N. M. J. Edelstyn*
Affiliation:
University Department of Psychiatry, Queen Elizabeth Psychiatric Hospital, Birmingham
F. Oyebode
Affiliation:
University Department of Psychiatry, Queen Elizabeth Psychiatric Hospital, Birmingham
M. J. Riddoch
Affiliation:
School of Psychology, University of Birmingham
R. Soppitt
Affiliation:
University Department of Psychiatry, Queen Elizabeth Psychiatric Hospital, Birmingham
H. Moselhy
Affiliation:
University Department of Psychiatry, Queen Elizabeth Psychiatric Hospital, Birmingham
M. George
Affiliation:
University Department of Psychiatry, Queen Elizabeth Psychiatric Hospital, Birmingham
*
Dr N. M. J. Edelstyn, University Department of Psychiatry, Queen Elizabeth Psychiatric Hospital, Mindelsohn Way, Birmingham BI52QZ
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Abstract

Background

The relationship between midline structural defects and schizophrenia remains unclear, although a number of neuroradiological studies have reported an association between schizophrenia and a range of anomalies.

Method

Three patients are reported, each diagnosed with schizophrenia and neuroradiological evidence of midline structural anomalies. MRI scans are reported in conjunction with performance over a range of neuropsychological tests designed to assess frontal and lateralised cognitive functions.

Results

Evidence of anterior dysfunction was present in all three cases, while on an individual basis patients displayed varying patterns of preserved and dysfunctional cognitive processing.

Conclusion

The reported findings raise a number of interesting issues regarding the nature of hemispheric involvement in schizophrenia.

Type
Papers
Information
The British Journal of Psychiatry , Volume 170 , Issue 5 , May 1997 , pp. 416 - 421
Copyright
Copyright © 1997 The Royal College of Psychiatrists 

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