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Neuropeptide Concentrations in the Cerebrospinal Fluid of Depressed Patients Treated with Electroconvulsive Therapy

Corticotrophin-Releasing Factor, β-endorphin and Somatostatin

Published online by Cambridge University Press:  02 January 2018

Charles B. Nemeroff ,
Garth Bissette ,
Huda Akil  and
Max Fink
Charles B. Nemeroff*
Affiliation:
Department of Psychiatry and Pharmacology
Garth Bissette
Affiliation:
Department of Psychiatry, Duke University Medical Center, Durham, North Carolina 27710
Huda Akil
Affiliation:
Mental Health Research Institute, Department of Psychiatry, University of Michigan School of Medicine, Ann Arbor, Michigan 48109
Max Fink
Affiliation:
Department of Psychiatry, State University of New York at Stony Brook, Stony Brook, New York 11780, USA
*
∗Box 3859, Duke University Medical Center, Durham, NC 27710, USA
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Abstract

The CSF concentrations of CRF, somatostatin and β-endorphin were determined in nine patients who fulfilled DSM–III criteria for major depression with psychotic features. CSF samples were obtained at baseline in the depressed state, and again after a course of ECT. Concentrations of both CRF and β-endorphin decreased after ECT, while the concentration of somatostatin increased, although the latter difference did not attain statistical significance. The increase in CSF concentrations of CRF and β-endorphin in depressed patients is therefore seen to be state-dependent.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 158 , Issue 1 , January 1991 , pp. 59 - 63
Copyright
Copyright © The Royal College of Psychiatrists 

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References

Abrams, R. & Fink, M. (1984) The present status of unilateral ECT: some recommendations. Journal of Affective Disorders, 7, 245–247.CrossRefGoogle ScholarPubMed
Akil, H., Young, E., Walker, J. M., et al (1986) The many possible roles of opioids and related peptides in stress-induced analgesia. Annals of the New York Academy of Sciences, 467, 140–153.CrossRefGoogle ScholarPubMed
American Psychiatric Association (1978) Electroconvulsive Therapy (Task Force Report No. 14). Washington, DC: APA.Google Scholar
American Psychiatric Association (1980) Diagnostic and Statistical Manual of Mental Disorders (3rd edn) (DSM–III). Washington, DC: APA.Google Scholar
Arato, M., Banki, C. M., Bissette, G. et al (1988) Elevated cerebrospinal fluid concentrations of corticotrophin-releasing factor in suicide victims. Biological Psychiatry, 23, 86–88.Google Scholar
Asberg, M., Thoren, P., Trasken, L., et al (1976) Serotonin depression – a biochemical subgroup within the affective disorders. Science, 191, 478–480.Google Scholar
Banki, C. M., Bissette, G., Arato, M., et al (1987) Cerebrospinal fluid corticotrophin-releasing factor-like immunoreactivity in depression and schizophrenia. American Journal of Psychiatry, 144, 873–877.Google Scholar
Berger, P. A. & Nemeroff, C. B. (1987) Opioid peptides in affective disorders. In Psychopharmacology, The Third Generation of Progress (ed. H. Y. Meltzer). New York: Raven Press.Google Scholar
Bissette, G., Widerlov, E., Walleus, H., et al (1986) Alterations in cerebrospinal fluid concentrations of somatostatin-like immunoreactivity in neuropsychiatric disorders. Archives of General Psychiatry, 43, 1148–1154.CrossRefGoogle ScholarPubMed
Cahill, C. A., Matthews, J. D. & Akil, H. (1983) Human plasma β-endorphin-like peptides: a rapid, high recovery extraction technique and validation of radioimmunoassay. Journal of Clinical Endocrinology and Metabolism, 56, 992–997.CrossRefGoogle ScholarPubMed
Carroll, B. J., Feinberg, M., Greden, J. F., et al (1981) A specific laboratory test for the diagnosis of melancholia. Archives of General Psychiatry, 38, 15–22.Google Scholar
Chappell, P. B., Smith, M. A., Kilts, C. D., et al (1986) Alterations in corticotrophin-releasing factor-like immunoreactivity in discrete rat brain regions after acute and chronic stress. Journal of Neuroscience, 6, 2908–2914.Google Scholar
Davis, K. L., Davidson, M., Yang, R.-K., et al (1988) CSF somatostatin in Alzheimer's disease, depressed patients, and control subjects. Biological Psychiatry, 24, 710–712.Google Scholar
Deakin, J. F., Ferrier, I. N., Crow, T. J., et al (1983) Effects of ECT on pituitary hormone release: relationship to seizure, clinical variables and outcome. British Journal of Psychiatry, 143, 618–624.Google Scholar
Doyle, M. C., George, A. J., Ravindran, A. V., et al (1985) Platelet α2–adrenoreceptor binding in elderly depressed patients. American Journal of Psychiatry, 142, 1489–1490.Google Scholar
Fink, M. (1979) Convulsive Therapy: Theory and Practice. New York: Raven Press.Google Scholar
Fink, M. (1984) Theories of the antidepressant efficacy of convulsive therapy (ECT). In Neurobiology of Manic Depresive Illness (eds R. M. Post & J. C. Ballenger). Baltimore: Williams & Wilkins.Google Scholar
Fink, M. (1987) Neuroendocrine aspects of convulsive therapy: review of recent developments. In Handbook of Clinical Psychoneuroendocrinology (eds C. B. Nemeroff & P. T. Loosen). New York: Guilford Press.Google Scholar
Fink, M. & Ottosson, J.-O. (1980) A theory of convulsive therapy in endogenous depression: significance of hypothalamic functions. Psychiatry Research, 2, 49–61.Google Scholar
Fink, M. & Johnson, L. (1982) Monitoring duration of ECT seizures: ‘cuff and EEG methods compared. Archives of General Psychiatry, 39, 1189–1191.CrossRefGoogle ScholarPubMed
Fink, M., Gujavarty, K. & Greenberg, L. (1987) Serial dexamethasone suppression tests and clinical outcome in ECT. Convulsive Therapy, 3, 111–120.Google Scholar
France, R. D., Urban, B., Krishnan, K. R. R., et al (1988) CSF corticotrophin-releasing factor-like immunoreactivity in chronic pain patients with and without major depression. Biological Psychiatry, 23, 86–88.Google Scholar
Gold, P. W., Chrousos, G., Kellner, C., et al (1984) Psychiatric implications of basic and clinical studies with corticotrophin-releasing factor. American Journal of Psychiatry, 141, 619–627.Google Scholar
Grahame-Smith, D. G., Green, A. R. & Costain, D. W. (1978) Mechanism of the antidepressant action of electroconvulsive therapy. Lancet, i, 254–256.CrossRefGoogle Scholar
Hamilton, M. (1967) Development of a rating scale for primary depressive illness. British Journal of Social and Clinical Psychology, 6, 278–296.Google Scholar
Holsboer, F., von Bardeleban, U. V., Gerken, A., et al (1984) Blunted corticotrophin and normal Cortisol response to human corticotrophin-releasing factor in depression. New England Journal of Medicine, 311, 1127.Google Scholar
Koob, G. F. & Thatcher-Britton, K. (1985) Stimulant and anxiogenic effects of corticotrophin-releasing factor. In Endocoids (eds H. Lal, F. LaBella & J. Lane). New York: Alan R. Liss.Google Scholar
Lancer, S. Z., Galzin, A. M., Lee, C. R., et al (1986) Antidepressant-binding sites in brain and platelets. In Antidepressants and Receptor Function (CIBA Foundation Symposium 123). Chichester: Wiley.Google Scholar
Lerer, B. (1984) Electroconvulsive shock and neurotransmitter receptors: implications for the mechanism of action of electroconvulsive therapy. Biological Psychiatry, 19, 361–383.Google ScholarPubMed
Loosen, P. T. & Prange, A. J. Jr (1980) Thyrotrophin-releasing hormone (TRH): a useful tool for psychoneuroendocrine investigation. Psychoneuroendocrinology, 5, 63–80.Google Scholar
Maurer, R. & Reubi, J.-C. (1985) Somatostatin receptors. Journal of the American Medical Association, 253, 2741.Google Scholar
Nemeroff, C. B. (1988) The role of corticotrophin-releasing factor in the pathogenesis of major depression. Pharmacopsychiatry, 21, 76–82.Google Scholar
Nemeroff, C. B., Widerlov, E., Bissette, G., et al (1984) Elevated concentrations of CSF corticotrophin-releasing factor-like immunoreactivity in depressed patients. Science, 226, 1342–1344.Google Scholar
Nemeroff, C. B. & Bissette, G. (1986) Neuropeptides in psychiatric disorders. In American Handbook of Psychiatry, vol. VIII (eds P. A. Berger & H. K. H. Brodie). New York: Basic Books.Google Scholar
Nemeroff, C. B., Owens, M. J., Bissette, G., et al (1988a) Reduced corticotrophin-releasing factor (CRF) binding sites in the frontal cortex of suicides. Archives of General Psychiatry, 45, 577–579.CrossRefGoogle Scholar
Nemeroff, C. B., Knight, D. L., Krishnan, K. R. R., et al (1988b) Marked reduction in the number of platelet [3H]-imipramine binding sites in geriatric depression. Archives of General Psychiatry, 45, 919–923.Google Scholar
Reynolds, C. F. III & Shipley, J. E. (1985) Sleep in depressive disorders. In Psychiatry Update, Vol. 4. Washington, DC: APA.Google Scholar
Rubinow, D. R., Gold, P. W., Post, R. M., et al (1983) CSF somatostatin in affective illness. Archives of General Psychiatry, 40, 409–412.Google Scholar
Sirinathsinghji, D. J. S., Rees, L. H., Rivier, J., et al (1983) Corticotrophin-releasing factor is a potent inhibitor of sexual receptivity in the female rat. Nature, 305, 232–235.CrossRefGoogle ScholarPubMed
Young, E. A., Bronstein, D. M. & Akil, H. (1989) Stimulation of β-endorphin release from rat hypothalamus in vitro. Society for Neuroscience Abstract, 15, 185.Google Scholar
Whalley, L. J., Rosie, R., Dick, H., et al (1982) Immediate increases in plasma prolactin and neurophysin but not other hormones after electroconvulsive therapy. Lancet, ii, 1064–1068.Google Scholar
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