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Neuroleptics in the Short-Term Treatment of Anorexia Nervosa a Double-blind Placebo-Controlled Study with Sulpiride

Published online by Cambridge University Press:  29 January 2018

W. Vandereycken
W. Vandereycken*
Affiliation:
University Psychiatric Center St-Jozef, Leuvensesteenweg 517, B-3070 Kortenberg, Belgium
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Summary

There is a remarkable lack of controlled investigations about the usefulness of psychotropic drugs in anorexia nervosa despite the popular use of neuroleptics in these patients. Inspired by a previous study using pimozide, a double-blind placebo-controlled cross-over study with sulpiride was carried out in 18 female anorexia nervosa inpatients. No direct effect of sulpiride has been established with regard to behavioural and attitudinal characteristics as measured by behaviour observation scales as well as by two self-report questionnaires (Eating Attitudes Test, Body Attitudes Test). Regarding daily weight gain, sulpiride was on the whole superior to placebo, especially in the first treatment period of three weeks. In the cross-over analysis, however, this effect did not reach statistical significance.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 144 , Issue 3 , March 1984 , pp. 288 - 292
Copyright
Copyright © 1984 The Royal College of Psychiatrists 

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