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Neuroleptic Serum Levels Measured by Radioreceptor Assay in Patients Receiving Intramuscular Depot Neuroleptics Some Preliminary Findings

Published online by Cambridge University Press:  29 January 2018

John Turbott ,
John Villiger  and
Lynley Hunter
John Turbott
Affiliation:
Department of Psychiatry
John Villiger
Affiliation:
Department of Pharmacology
Lynley Hunter
Affiliation:
Department of Psychiatry, School of Medicine, University of Auckland, Private Bag, Auckland, New Zealand
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Summary

Twenty-six chronic schizophrenic patients on well established depot neuroleptic regimes with stable doses (16 on fluphenazine decanoate, ten on flupenthixol decanoate) had serum neuroleptic levels measured by a radioreceptor assay (RRA) method. The assay was sufficiently sensitive to measure serum levels in all cases, with acceptable levels of inter-assay variation. Blood level measurements were repeated on two occasions, at the same time interval from the last injection, in 18 patients (11 on fluphenazine decanoate, seven on flupenthixol decanoate) and remained reasonably stable in most cases, although others showed a wider variation. Despite a wide range of doses (× 32 fluphenazine decanoate, × 21 flupenthixol decanoate) the serum levels fell in a remarkably narrow range (× 4, × 6). There was a significant correlation between dose and blood level for flupenthixol decanoate, but not for fluphenazine decanoate.

Type
Brief Reports
Information
The British Journal of Psychiatry , Volume 146 , Issue 4 , April 1985 , pp. 439 - 442
Copyright
Copyright © 1985 The Royal College of Psychiatrists 

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