Hostname: page-component-586b7cd67f-g8jcs Total loading time: 0 Render date: 2024-11-25T20:06:26.975Z Has data issue: false hasContentIssue false
  • English
  • Français

Neuroleptic Serum Levels Measured by Radioreceptor Assay in Patients Receiving Intramuscular Depot Neuroleptics Some Preliminary Findings

Published online by Cambridge University Press:  29 January 2018

John Turbott ,
John Villiger  and
Lynley Hunter
John Turbott
Affiliation:
Department of Psychiatry
John Villiger
Affiliation:
Department of Pharmacology
Lynley Hunter
Affiliation:
Department of Psychiatry, School of Medicine, University of Auckland, Private Bag, Auckland, New Zealand
Get access Rights & Permissions [Opens in a new window]

Summary

Twenty-six chronic schizophrenic patients on well established depot neuroleptic regimes with stable doses (16 on fluphenazine decanoate, ten on flupenthixol decanoate) had serum neuroleptic levels measured by a radioreceptor assay (RRA) method. The assay was sufficiently sensitive to measure serum levels in all cases, with acceptable levels of inter-assay variation. Blood level measurements were repeated on two occasions, at the same time interval from the last injection, in 18 patients (11 on fluphenazine decanoate, seven on flupenthixol decanoate) and remained reasonably stable in most cases, although others showed a wider variation. Despite a wide range of doses (× 32 fluphenazine decanoate, × 21 flupenthixol decanoate) the serum levels fell in a remarkably narrow range (× 4, × 6). There was a significant correlation between dose and blood level for flupenthixol decanoate, but not for fluphenazine decanoate.

Type
Brief Reports
Information
The British Journal of Psychiatry , Volume 146 , Issue 4 , April 1985 , pp. 439 - 442
Copyright
Copyright © 1985 The Royal College of Psychiatrists 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Brown, W. A., Laughren, T., Chisholm, E. & Williams, B. W. (1982) Low serum neuroleptic levels predict relapse in schizophrenic patients. Archives of General Psychiatry, 39, 998–1000.Google Scholar
Cohen, B. M., Lipinski, J. F., Harris, P. Q., Harrison, G. P. & Friedman, M. (1980) Clinical use of radioreceptor assay for neuroleptics. Psychiatry Research, 1, 173–178.CrossRefGoogle Scholar
Creese, I. & Snyder, S. H. (1977) A simple and sensitive radioreceptor assay for antischizophrenic drugs in blood. Nature, 270, 180–182.Google Scholar
Curry, S. H., Whelpton, R., de Schepper, P. J., Vranckx, S. & Schiff, A. A. (1979) Kinetics of fluphenazine after fluphenazine dihydrochloride, enanthate and decanoate administration to man. British Journal of Clinical Pharmacology, 7, 325–331.Google Scholar
Javaid, J. I., Davis, J. M., Dysken, M. W., Janicak, P. & Casper, R. (1983) Neuroleptic concentrations in schizophrenic patients: measurement by radioreceptor assay and gas chromatography. Psychopharmacology Bulletin, 19, 72–74.Google Scholar
Lader, S. R. (1980) A radioreceptor assay for neuroleptic drugs in plasma. Journal of Immunoassay, 1(1), 57–75.Google Scholar
Overall, J. E. & Gorham, D. R. (1962). The Brief Psychiatric Rating Scale. Psychological Reports, 10, 799–812.CrossRefGoogle Scholar
Spitzer, R. C., Endicott, J. & Robins, E. (1978) Research Diagnostic Criteria (RDC) for a selected group of functional disorders. New York State Psychiatric Institute.Google Scholar
Tune, L. E., Creese, I., Coyle, J. T., Pearlson, G. & Snyder, S. H. (1980) Low neuroleptic serum levels in patients receiving fluphenazine decanoate. American Journal of Psychiatry, 137, 80–82.Google ScholarPubMed
Tune, L. E., Creese, I., Coyle, J. T., Pearlson, G., de Paulo, J. R., Slavney, P. R. & Snyder, S. H. (1981) Neuroleptic serum levels measured by radioreceptor assay and clinical response in schizophrenic patients. The Journal of Nervous and Mental Disease. 169, 60–63.CrossRefGoogle ScholarPubMed
Wiles, D. H. & Gelder, M. G. (1979) Plasma fluphenazine levels by radioimmunoassay in schizophrenic patients treated with depot injections of fluphenazine decanoate. British Journal of Clinical Pharmacology, 8, 565–570.CrossRefGoogle ScholarPubMed
Submit a response

eLetters

No eLetters have been published for this article.