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Neurochemical alterations in schizophrenia affecting the putative receptor targets of atypical antipsychotics

Focus on dopamine (D1, D3, D4) and 5-HT2a receptors

Published online by Cambridge University Press:  06 August 2018

P. J. Harrison
P. J. Harrison*
Affiliation:
University Department of Psychiatry, Warneford Hospital, Oxford OX3 7JX. Tel: 01865 226463; Fax: 01865251076; e-mail: [email protected]
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Extract

What mechanisms make an antipsychotic atypical? A common view is that the different therapeutic and side-effect profile of atypical compared to typical antipsychotics is due to their high affinity for specific dopamine and/or 5-HT (serotonin) receptors. Dopamine D4 and 5-HT2a receptors are particularly implicated, though many others have been proposed as well, including dopamine D1 and D3, 5-HT1a, 5-HT2c, 5-HT6, 5-HT7 and α2 adrenergic receptors (for review, see Deutch et al, 1991; Ashby & Wang, 1996; Kinon & Lieberman, 1996).

Type
Research Article
Information
The British Journal of Psychiatry , Volume 174 , Issue S38: New antipsychotics - preclinical and clinical comparisons , May 1999 , pp. 12 - 22
Copyright
Copyright © 1999 The Royal College of Psychiatrists 

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