Hostname: page-component-586b7cd67f-dlnhk Total loading time: 0 Render date: 2024-11-25T19:59:47.540Z Has data issue: false hasContentIssue false
  • English
  • Français

Multivariate genetic analysis of the causes of temperance board registrations

In all Swedish male-female twin pairs born 1926–1949

Published online by Cambridge University Press:  02 January 2018

Kenneth S. Kendler ,
Laura M. Karkowski ,
Carol A. Prescott ,
Michael C. Neale  and
Nancy L. Pedersen
Kenneth S. Kendler*
Affiliation:
Department of Psychiatry, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA, USA
Laura M. Karkowski
Affiliation:
Department of Psychiatry, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA, USA
Carol A. Prescott
Affiliation:
Department of Psychiatry, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA, USA
Michael C. Neale
Affiliation:
Department of Psychiatry, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA, USA
Nancy L. Pedersen
Affiliation:
Division of Genetic Epidemiology, Institute for Environmental Medicine, The Karolinska Institute, Stockholm, Sweden
*
Dr Kendler, PO Box 980126, Richmond, Virginia 23298-0126, USA
Get access Rights & Permissions [Opens in a new window]

Abstract

Background

The Temperance Boards in Sweden registered individuals for three reasons: public drunkenness, driving under the influence of alcohol and committing a crime in connection with alcohol. We wanted to ascertain whether these three forms of alcohol-related problems result from similar or different genetic and environmental risk factors.

Method

We conducted a trivariate twin analysis of these three causes of registration in all male-female twin pairs of known zygosity born in Sweden, 1926–1949 (n=5177 twin pairs).

Results

Prevalences of registration for public drunkenness, drink-driving and alcohol-related crime were, respectively, 9.0, 3.6 and 4.0%. The best-fitting model had one general genetic and one general familial – environmental factor with specific genetic risk factors for drink-driving and specific familial – environmental risk factors for alcohol-related crime.

Conclusions

The three causes for alcohol registration in Sweden largely reflect the same genetic and environmental risk factors. Estimated heritabilities were similar for the three forms of registration. However, specific genetic risk factors exist for drink-driving and specific familial – environmental risk factors for alcohol-related crime. Genetic factors are somewhat less important and familial –environmental factors more important for public drunkenness than for drink-driving and alcohol related crime.

Type
Papers
Information
The British Journal of Psychiatry , Volume 172 , Issue 3 , March 1998 , pp. 268 - 272
Copyright
Copyright © 1998 The Royal College of Psychiatrists 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Akaike, H. (1987) Factor analysis and AIC. Psychometrika, 52, 317–332.CrossRefGoogle Scholar
Amark, C. (1951) A study in alcoholism: clinical, social-psychiatric and genetic investigations. Acta Psychiatrica et Neurologica Scandinavica Supplementum, 70, 1–283.Google ScholarPubMed
Babor, T. F. (1996) The classification of alcoholics: typology theories from the 19th century to the present. Alcohol Health and Research World, 20, 6–14.Google Scholar
Bohman, M., Cloninger, C. R., Sigvardsson, S., et al (1982) Predisposition to petty criminality in Swedish adoptees: I. Genetic and environmental heterogeneity. Archives of General Psychiatry, 39, 1233–1241.Google Scholar
Caderlof, R., Friberg, L., Jonsson, E., et al (1961) Studies on similarity diagnosis in twins with the aid of mailed questionnaires. Acta Genetica et Statistica Medico, 11, 338–362.Google Scholar
Cloninger, C. R. (1987) Neurogenetic adaptive mechanisms in alcoholism. Science, 236, 410–416.Google Scholar
Cloninger, C. R., Bohman, M. & Sigvardsson, S. (1981) Inheritance of alcohol abuse: cross-fostering analysis of adopted men. Archives of General Psychiatry, 38. 861–868.CrossRefGoogle ScholarPubMed
Cloninger, C. R., Przybeck, T. R., Svrakic, D. M., et al (1994) The Temperament and Character Inventory (TCI): A Guide to Its Development and Use. St Louis: Center for Psychobiology of Personality. Washington University.Google Scholar
Dahlberg, G. (1942) The occurrence of alcoholics and their treatment: a social-statistical analysis for the town of Malmö 1929–1938. Acta Medica Scandinavica, 111. 325–358.CrossRefGoogle Scholar
Feild, H. S. & Armenakis, A. A. (1974) On use of multiple tests of significance in psychological research. Psychological Reports, 35, 427–431.Google Scholar
Hjörtzberg-Nordlund, H. (1968) Abuse of alcohol in middle-aged men in Göteborg: A social psychiatric investigation. Acta Psychiatrica Scandinavica, 44 (suppl. 199), 1–127.Google Scholar
Joreskog, K. G. & Sorbom, D. (1988) PRELIS: A Preprocessor for LISREL. Mooresville, IN: Scientific Software.Google Scholar
Kendler, K. S. (1993) Twin studies of psychiatric illness: current status and future directions. Archives of General Psychiatry, 50. 905–915.CrossRefGoogle ScholarPubMed
Kendler, K. S., Heath, A. C., Martin, N. G., et al (1987) Symptoms of anxiety and symptoms of depression: same genes, different environments? Archives of General Psychiatry, 44, 451–457.CrossRefGoogle ScholarPubMed
Kendler, K. S., Prescott, C. A., Neale, M. C., et al (1997) Temperance board registration for alcohol abuse in a national sample of Swedish male twins born 1902–1949. Archives of General Psychiatry, 54.178–184.Google Scholar
McArdle, J. J. & Goldsmith, H. H. (1990) Alternative common-factor models for multivariate biometric analyses. Behavior Genetics, 20, 569–608.CrossRefGoogle ScholarPubMed
Medlund, P., Cederlof, R., Floderus-Myrhed, B., et al (1977) A Swedish twin registry. Acta Medica Scandinavica, Supplementum, 600.Google Scholar
Neale, M. C. & Cardon, L. R. (1992) Methodology for Genetic Studies of Twins and Families, pp. 248–253. Dordrecht. The Netherlands: Kluwer Academic.CrossRefGoogle Scholar
Reich, W. & Earls, F. (1990) Interviewing adolescents by telephone: is it a useful methodological strategy? Comprehensive Psychiatry, 31, 211–215.Google Scholar
Robins, L. N. (1966) Deviant Children Grown Up. Baltimore, MD: Williams & Wilkins.Google Scholar
Rutter, M. (1978) Family, area and school influences in the genesis of conduct disorders. In Aggression and Anti-Social behaviour in Childhood and Adolescence (eds Hersov, L. A. & Berger, M. A.), pp. 95–114. London: Pergamon.Google Scholar
Sigvardsson, S., Bohman, M. & Cloninger, C. R. (1996) Replication of the Stockholm Adoption Study of alcoholism: confirmatory cross-fostering analysis. Archives of General Psychiatry, 53, 681–687.Google Scholar
Williams, L. J. & Holahan, P. J. (1994) Parsimony-based fit indices for multiple-indicator models: do they work? Structural Equation Modeling, 1, 161–189.Google Scholar
Zuckerman, M. (1972) Drug use as one manifestation of a ‘sensation-seeking trait’. In Drug Abuse: Current Concepts and Research (ed. Keup, W.), pp. 154–163. Springfield. IL: Charles C. Thomas.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.