Hostname: page-component-78c5997874-94fs2 Total loading time: 0 Render date: 2024-11-01T05:53:33.027Z Has data issue: false hasContentIssue false
  • English
  • Français

Mineral Metabolism in Affective Disorders

Published online by Cambridge University Press:  29 January 2018

Alec Coppen
Alec Coppen*
Affiliation:
Medical Research Council Neuropsychiatric Research Unity Carshalton and Greenbank, West Park Hospital, Epsom, Surrey
Get access Rights & Permissions [Opens in a new window]

Extract

Physiological research has shown the fundamental importance of electrolytes in the functioning of the cell. According to the ionic theory, the resting and action potentials of nerve and muscle cells depend on potassium, sodium, chloride and other ions having a different concentration inside the cell to the concentration they have in the extracellular fluid. The cell membrane is freely permeable to potassium and chloride, but is much less permeable to sodium, and there is active transport of sodium which keeps the sodium concentration within the cell at about 1/10 of the concentration of sodium in the extracellular space. Because of this uneven distribution of sodium and the presence within the cell of impermeable anions (such as glutamic acid), potassium and chlorine are also unevenly divided between the cell and the extracellular fluid; potassium has a very high intracellular concentration and chlorine a low intracellular concentration compared to their concentration in the extracellular space.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 111 , Issue 481 , December 1965 , pp. 1133 - 1142
Copyright
Copyright © Royal College of Psychiatrists, 1965 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Coppen, A. J. (1960). J. Neurol. Neurosurg. Psychiat., 23, 156.CrossRefGoogle Scholar
Coppen, A. J., Shaw, D. M., and Mangoni, A. (1962). Brit. med. J., ii, 295.CrossRefGoogle Scholar
Coppen, A. J., Shaw, D. M., and Mangoni, A. (1963). Ibid., ii, 1439.Google Scholar
Coppen, A., Costain, R., Malleson, A., and Shaw, D. M. (1965). To be published.Google Scholar
Coppen, A., Costain, R., Malleson, A., Malleson, A., and Shaw, D. M. (1965). Lancet, i, 682.Google Scholar
Gartside, I., Lippold, O., and Meldrum, B. (1965). To be published.Google Scholar
Gibbons, J. L. (1960). Clin. Sci., 19, 133.Google Scholar
Hartigan, G. P. (1963). Brit. J. Psychiat., 109, 810.Google Scholar
Hildrith, H. M. (1946). J. clin. Psychol., 2, 214.3.0.CO;2-J>CrossRefGoogle Scholar
Keynes, R. D., and Swan, R. C. (1959). J. Physiol., 147, 626.Google Scholar
Maggs, R. (1963). Brit. J. Psychiat., 109, 56.CrossRefGoogle Scholar
Moore, F. D., Olesen, K. H., McMurrey, J. D., Parker, H. V., Ball, M. R., and Boyden, C. M. (1963). The Body Cell Mass and its Supporting Environment. Saunders. Philadelphia.Google Scholar
Nichols, G., and Nichols, N. (1956). Metabolism, 5, 438.Google ScholarPubMed
Russell, G. F. M. (1960). Clin. Sci., 19, 327.Google Scholar
Schottstaedt, W. W., Grace, W. J., and Wolff, H. G. (1956). J. psychosom. Res., 1, 287.Google Scholar
Schou, M. (1957). Pharmacol. Rev., 9, 17.Google Scholar
Shagass, G., and Schwartz, M. (1962) in Physiological Correlates of Psychological Disorder (edited by R. Roessler and N. S. Greenfield), p. 45. Madison.Google Scholar
Zerahn, K. (1955). Acta physiol. scand., 35, 347.CrossRefGoogle Scholar
Submit a response

eLetters

No eLetters have been published for this article.