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Midline brain anomalies and schizophrenia in people with CATCH 22 syndrome

Published online by Cambridge University Press:  03 January 2018

R. Vataja  and
Eero Elomaa
R. Vataja*
Affiliation:
Department of Psychiatry, Helsinki University Hospital, Helsinki, Finland
Eero Elomaa
Affiliation:
Kellokoski Hospital, Finland
*
Dr R. Vataja, Helsinki University Hospital, Department of Psychiatry, Lapinlahdentie, 00290 Helsinki, Finland
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Abstract

Background

Since people with chromosome 22q11 deletion (CATCH 22 syndrome) have unexpectedly high incidence of major psychosis it has been suggested that 22q area might be involved in the pathogenesis of schizophrenia and bipolar disorders.

Method

A single case report.

Results

A 32-year-old male patient with CATCH 22 syndrome and schizophrenia had extensive midline anomalies of the brain in the regions relevant to psychotic disorders.

Conclusions

22q11-dependent abnormalities in the midline structures of the brain may cause dysfunction in the limbic system and interfere with the interhemispheric information exchange thus predisposing people with CATCH 22 syndrome to psychotic disorders.

Type
Papers
Information
The British Journal of Psychiatry , Volume 172 , Issue 6 , June 1998 , pp. 518 - 520
Copyright
Copyright © 1998 The Royal College of Psychiatrists 

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