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Long-Term Phenothiazine Treatment does not Cause Pituitary Tumours

Published online by Cambridge University Press:  29 January 2018

Victoria A. Lilford ,
R. J. Lilford ,
Janet E. Dacie ,
Lesley A. Rees  and
T. Chard
Victoria A. Lilford
Affiliation:
Stamford Hill Group Practice, London N16 (previously Friern Barnet Psychiatric Hospital)
R. J. Lilford*
Affiliation:
Department of Obstetrics and Gynaecology, and Reproductive Physiology, St Bartholomew's Hospital Medical College and The London Hospital Medical College, Turner Street, London E1
Janet E. Dacie
Affiliation:
Department of Diagnostic Radiology, St Bartholomew's Hospital, London
Lesley A. Rees
Affiliation:
St Bartholomew's Hospital Medical College, London
T. Chard
Affiliation:
Department of Obstetrics, Gynaecology and Reproductive Physiology, St Bartholomew's Hospital, London
*
∗Correspondence.
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Summary

In order to explore the possibility that prolactinomas may be caused by prolonged under-inhibition of prolactin-secreting cells we examined the pituitary fossa in 69 patients on long-term phenothiazine treatment. The average duration of treatment was 12.5 years and 55 (80 per cent) of the patients had persistently raised serum prolactin levels. The incidence of radiologically detectable pituitary fossa abnormalities was not significantly different to that in control populations. In 62 per cent of patients the skull x-rays from an earlier admission were available. Comparison of these with earlier films did not show a higher incidence of pituitary fossa abnormalities after prolonged exposure to phenothiazines.

Type
Papers
Information
The British Journal of Psychiatry , Volume 144 , Issue 4 , April 1984 , pp. 421 - 424
Copyright
Copyright © 1984 The Royal College of Psychiatrists 

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References

Banna, M., Ferns, J. A. J., McLean, R. T. & Thompson, M. A. (1983) Anatomico-radiological study of the borderline sella. British Journal of Radiology, 56, 1–5.Google Scholar
Burrow, G. M., Wortzman, G., Rewcastle, M. B., Holgate, R. C. & Kovacs, K. (1981) Microadenomas of the pituitary and abnormal sellar tomograms in an unselected autopsy series. New England Journal of Medicine, 304, 156–8.Google Scholar
Carlsson, A. (1977) Does dopamine play a role in schizophrenia. Psychological Medicine, 7, 583–9.Google Scholar
Chang, R. J., Keye, W. R., Young, J. R., Wilson, C. B. & Jaffe, R. B. (1977) Detection, evaluation and treatment of pituitary microadenomas in patients with galactorrhoea and amenorrhoea. American Journal of Obstetrics and Gynaecology, 128, 356–63.CrossRefGoogle Scholar
Del Pozo, E. & Brownell, J. (1979) Prolactin. I. Mechanisms of control, peripheral actions and modifications by drugs. Hormone Research, 108, 143–72.Google Scholar
Frantz, A. E., Kleinberg, D. & Noel, G. L. (1972) Studies on prolactin. Recent Progress in Hormone Research, 28, 527–90.Google Scholar
George, S. R., Burrow, G. M., Zinnman, B. & Ezrin, C. (1979) Regression of pituitary tumours, a possible effect of bromergo/cryptine. American Journal of Medicine, 66, 967–70.Google Scholar
Jung, R. J., White, M. C., Bowley, N. B., Bydder, G., Mashiter, K. & Joplin, G. F. (1982) CT abnormalities of the pituitary in hyperprolactinaemic women with normal or equivocal sellae radiologically. British Medical Journal, 285, 1078–81.Google Scholar
Klinj, J. G. M., Cambert, S. W. J., De Jong, F. A., Docter, R., Van Dongen, K. J. & Birkanhager, J. C. (1980) The importance of pituitary tumour size in patients with hyperprolactinaemia in relation to hormonal variables and extrasellar extension of tumour. Clinical Endocrinology, 12, 341–55.Google Scholar
Lal, S. & Nair, M. P. U. (1980) Effects of neuroleptics on prolactin and growth hormone secretion in man. In: Neuroactive Drugs in Endocrinology (ed. E. E. Muller). Amsterdam: Elsevier, North Holland Biomedical Press.Google Scholar
McLochlan, M. S. F. & Banna, M. (1979) Observer variation in interpreting radiographs of the pituitary fossa. Investigative Radiology, 14, 23–6.Google Scholar
Swanson, H. A. & du Boulay, G. (1975) Borderline variants of the normal pituitary fossa. British Journal of Radiology, 48, 366–9.Google Scholar
Yen, S. C. C., Ehara, Y. & Siler, T. M. (1974) Augmentation of prolactin secretion by estrogen in hypogonadal women. Journal of Clinical Investigation, 53, 652–5.Google Scholar
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