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Is the Concept of Frontal–Subcortical Dementia Relevant to Schizophrenia?

Published online by Cambridge University Press:  02 January 2018

Christos Pantelis ,
Thomas R. E. Barnes  and
Hazel E. Nelson
Christos Pantelis*
Affiliation:
Charing Cross & Westminster Medical School, Schizophrenia Research Programme, Academic Unit, Horton Hospital, Long Grove Rd, Epsom, Surrey KT19 8PZ
Thomas R. E. Barnes
Affiliation:
Charing Cross & Westminster Medical School, Schizophrenia Research Programme, Academic Unit, Horton Hospital
Hazel E. Nelson
Affiliation:
Department of Psychology, Horton Hospital
*
∗Correspondence
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Abstract

A syndrome of subcortical dementia has been described in conditions predominantly affecting the basal ganglia or thalamus, structures that have also been implicated in the pathogenesis of schizophrenia. There are similarities between subcortical dementia and the type II syndrome of schizophrenia, in terms of clinical features, pattern of neuropsychological deficits, pathology, biochemistry and data from brain-imaging studies. These similarities raise the possibility that certain schizophrenic symptoms, particularly negative symptoms and disturbance of movement, may reflect subcortical pathology. Neuropsychological deficits of presumed frontal lobe origin have been reported in some schizophrenic subjects. The occurrence of such deficits in a condition in which frontal lobe pathology has not been clearly demonstrated may be explicable in terms of a subcortical deafferentation of the pre-frontal cortex.

Type
Review Article
Information
The British Journal of Psychiatry , Volume 160 , Issue 4 , April 1992 , pp. 442 - 460
Copyright
Copyright © Royal College of Psychiatrists, 1992 

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