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Increased Plasma LH in Manic-Depressive Illness: Evidence of a State-Independent Abnormality

Published online by Cambridge University Press:  02 January 2018

L. J. Whalley ,
S. Kutcher ,
D. H. R. Blackwood ,
J. Bennie ,
H. Dick  and
G. Fink
L. J. Whalley*
Affiliation:
MRC Brain Metabolism Unit
S. Kutcher
Affiliation:
MRC Brain Metabolism Unit, Edinburgh
D. H. R. Blackwood
Affiliation:
MRC Brain Metabolism Unit, Edinburgh
J. Bennie
Affiliation:
MRC Brain Metabolism Unit, Edinburgh
H. Dick
Affiliation:
MRC Brain Metabolism Unit, Edinburgh
G. Fink
Affiliation:
MRC Brain Metabolism Unit, Edinburgh
*
∗University Department of Psychiatry, Royal Edinburgh Hospital, Morningside Park, Edinburgh EH10 5HF
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Abstract

Basal plasma luteinising hormone concentrations and the LH responses to LH-releasing hormone injection were higher in 11 young men after recovery from mania than in 15 control subjects. Since plasma concentrations of testosterone and sex hormone binding globulin were similar in the recovered manic compared with the control subjects, the increased LH response to LHRH is likely to have been due to the priming effect of LHRH consequent on an increased release of LHRH into hypophysial portal vessel blood. Abnormal control of LHRH, and thereby LH release, is a state-independent feature in male patients with mania and may be a useful trait marker for this disorder.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 150 , Issue 5 , May 1987 , pp. 682 - 684
Copyright
Copyright © 1987 The Royal College of Psychiatrists 

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