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Impaired In Vivo Immune Responses in Patients with Melancholia

Published online by Cambridge University Press:  02 January 2018

Ian Hickie ,
Catherine Hickie ,
Andrew Lloyd ,
Derrick Silove  and
Denis Wakefield
Ian Hickie*
Affiliation:
Mood Disorders Unit, Division of Psychiatry, Prince Henry Hospital, Sydney, Australia, 2036
Catherine Hickie
Affiliation:
Mood Disorders Unit, Division of Psychiatry, Prince Henry Hospital, Sydney, Australia, 2036
Andrew Lloyd
Affiliation:
University of New South Wales, Department of Immunopathology, Prince Henry Hospital, Sydney
Derrick Silove
Affiliation:
University of New South Wales, Department of Immunopathology, Prince Henry Hospital, Sydney
Denis Wakefield
Affiliation:
Department of Psychiatry, Liverpool Hospital, University of New South Wales
*
∗Correspondence
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Abstract

Previous attempts to establish a relationship between impaired cell-mediated immunity (CMI) and major mood disorders have been limited by a failure to explore the relevance of depressive subcategories or to assess CMI by in vivo methods. In this case-control study CMI was assessed in 57 patients with major depression (31 with melancholic, 26 with non-melancholic disorders), and in age- and sex-matched controls by both in vitro and in vivo immunological techniques. Compared with control subjects and patients with non-melancholic depression, patients with melancholia demonstrated reduced in vivo CMI as assessed by delayed-type hypersensitivity (DTH) skin responses. Although increasing age, severity of depression, hospital admission for treatment, and reported weight loss are correlates of melancholia, none of these factors alone, or in combination, accounted for the differences in DTH responses observed between the two depressive subtypes. These data suggest that impaired CMI in vivo may be limited to those with melancholic disorders. At this stage the factors which account for this effect are unclear.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 162 , Issue 5 , May 1993 , pp. 651 - 657
Copyright
Copyright © Royal College of Psychiatrists, 1993 

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