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HLA-A2 Antigen in Schizophrenic Patients with Reversed Cerebral Asymmetry

Published online by Cambridge University Press:  29 January 2018

Daniel J. Luchins ,
Daniel R. Weinberger ,
E. Fuller Torrey ,
Armead Johnson ,
Nicholas Rogentine  and
Richard Jed Wyatt
Daniel J. Luchins
Affiliation:
Adult Psychiatry Branch, National Institute of Mental Health, WAW Bldg., St Elizabeth's Hospital, Washington, D.C. 20032
Daniel R. Weinberger
Affiliation:
Adult Psychiatry Branch, National Institute of Mental Health, WAW Bldg., St Elizabeth's Hospital, Washington, D.C. 20032
E. Fuller Torrey
Affiliation:
Noyes Division, St Elizabeth's Hospital
Armead Johnson
Affiliation:
Division of Immunology, Department of Microbiology, Duke University of Medical School, Durham, North Carolina
Nicholas Rogentine
Affiliation:
Immunology Branch, National Cancer Institute, Bethesda, Maryland
Richard Jed Wyatt
Affiliation:
Adult Psychiatry Branch, National Institute of Mental Health, WAW Bldg., St Elizabeth's Hospital, Washington, D.C. 20032
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Summary

The frequency of HLA-A2 was examined in 32 black and 22 white schizophrenic patients separated into two groups according to whether they had normal or reversed cerebral hemispheric asymmetries as determined by computed tomography. The black patients with reversed asymmetry had a significantly greater frequency of HLA-A2 as compared to black patients with normal asymmetry and a black normal control group. There were no significant differences for any other A, B or C antigens. These findings also held when only the 22 black patients without evidence of brain atrophy were studied. The results for the white patients were in the same direction but did not reach statistical significance. These findings suggest that, at least for black schizophrenic patients, reversed cerebral asymmetry is associated with an increased frequency of HLA-A2.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 138 , Issue 3 , March 1981 , pp. 240 - 243
Copyright
Copyright © Royal College of Psychiatrists, 1981 

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