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HLA Antigens in Schizophrenia: Differences between Patients with and without Evidence of Brain Atrophy

Published online by Cambridge University Press:  29 January 2018

Daniel Luchins ,
E. Fuller Torrey ,
Daniel R. Weinberger ,
Steven Zalcman ,
Lynn Delisi ,
Armead Johnson ,
Nicholas Rogentine  and
Richard Jed Wyatt
Daniel Luchins
Affiliation:
Laboratory of Clinical Psychopharmacology, National Institute of Mental Healthy WAW Bldg. St Elizabeths Hospital, Washington, DC
E. Fuller Torrey
Affiliation:
Noyes Division, St Elizabeths Hospital, Washington, DC
Daniel R. Weinberger
Affiliation:
Laboratory of Clinical Psychopharmacology
Steven Zalcman
Affiliation:
Laboratory of Clinical Psychopharmacology
Lynn Delisi
Affiliation:
Laboratory of Clinical Psychopharmacology
Armead Johnson
Affiliation:
Division of Immunology, Department of Microbiology, Duke University Medical School, Durham, NC
Nicholas Rogentine
Affiliation:
Immunology Branch, National Cancer Institute, Bethesda, Md
Richard Jed Wyatt
Affiliation:
Laboratory of Clinical Psychopharmacology
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Summary

A survey of 14 published studies found no consistent association between specific HLA antigens and schizophrenia. Since these studies lacked diagnostic or biological criteria, an investigation was undertaken using recognized diagnostic criteria and CT scan findings. Typing for HLA antigens at loci A, B and C was carried out on 130 patients. Among 92 black schizophrenic patients there was an increase of HLA-A2 which remained significant even after correcting for the number of antigens studied. When the patients for whom CT scans were available were divided according to the presence or absence of evidence of brain atrophy, there was an increase of A2 in the black schizophrenic patients without evidence of atrophy, which remained significant after multiplying by the number of antigens studied. However, there was no significant increase of A2 in those with evidence of atrophy. Similar trends held for the white population but they failed to reach significance. The need for HLA studies on biologically defined groups of schizophrenic patients is stressed.

Type
Papers
Information
The British Journal of Psychiatry , Volume 136 , Issue 3 , March 1980 , pp. 243 - 248
Copyright
Copyright © Royal College of Psychiatrists, 1980 

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