Hostname: page-component-cd9895bd7-jn8rn Total loading time: 0 Render date: 2024-12-31T20:00:01.626Z Has data issue: false hasContentIssue false
  • English
  • Français

Heritability of Schizophrenia

A Controlled Family History Investigation in Nigeria

Published online by Cambridge University Press:  02 January 2018

O. Gureje ,
R. Bamidele  and
Y. A. Aderibigbe
O. Gureje*
Affiliation:
Department of Psychiatry, University College Hospital, PMB 5116, Ibadan, Nigeria
R. Bamidele
Affiliation:
Department of Psychiatry, University College Hospital, PMB 5116, Ibadan, Nigeria
Y. A. Aderibigbe
Affiliation:
Department of Psychiatry, University College Hospital, PMB 5116, Ibadan, Nigeria
*
∗Correspondence
Get access Rights & Permissions [Opens in a new window]

Abstract

Thirty-six consecutively admitted patients with schizophrenia and 20 with mania were studied for the morbid risk of psychosis in their first-degree relatives. Using the family history method of ascertainment, the morbid risk for schizophrenia in the relatives of schizophrenic probands was 4.12% compared with 1.42% in the relatives of manic probands. While this difference was not statistically significant, that between the morbid risk for affective psychoses in the relatives of manic patients (7.81%) was significantly higher than for the relatives of schizophrenic patients (0%).

Type
Papers
Information
The British Journal of Psychiatry , Volume 164 , Issue 4 , April 1994 , pp. 481 - 486
Copyright
Copyright © 1994 The Royal College of Psychiatrists 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Abrams, R. & Taylor, M. A. (1983) The genetics of schizophrenia: A reassessment using modern criteria. American Journal of Psychiatry, 140, 171–175.Google Scholar
Andreasen, N. C., Endicott, J., Spitzer, R. L., et al (1977) The family history method using diagnostic criteria. Archives of General Psychiatry, 34, 1229–1235.CrossRefGoogle ScholarPubMed
Andreasen, N. C., Rice, J., Endicott, J., et al (1986) The family history approach to diagnosis: how useful is it? Archives of General Psychiatry, 43, 421–429.Google Scholar
Andreasen, N. C., Rice, J., Endicott, J., et al (1987) Familial rates of affective disorder. Archives of General Psychiatry, 44, 461–469.Google Scholar
Baron, M., Gruen, R., Asnis, L., et al (1982) Schizoaffective illness, schizophrenia and affective disorders: morbidity risk and genetic transmission. Acta Psychiatrica Scandinavica, 65, 253–262.CrossRefGoogle ScholarPubMed
Baron, M., Risch, N., Hamburger, R., et al (1987) Genetic linkage between X chromosome markers and manic depression. Nature, 326, 806–808.CrossRefGoogle Scholar
Breborowicz, G. & Trzebratowska-Trzeciak, O. (1976) A method for testing differences in morbidity risk for affective psychoses. Acta Psychiatrica Scandinavica, 54, 353–358.Google Scholar
Coryell, W. & Zimmerman, M. (1988) The heritability of schizophrenia and schizoaffective disorder: a family study. Archives of General Psychiatry, 45, 323–327.Google Scholar
Crow, T. J. (1986) The continuum of psychosis and its implication for the structure of the gene. British Journal of Psychiatry, 149, 419–429.CrossRefGoogle ScholarPubMed
Egeland, J. A. & Hostetter, A. M. (1983) Amish study: I. Affective disorders among the Amish, 1976–1980. American Journal of Psychiatry, 140, 56–71.Google Scholar
Egeland, J. A., Gerhard, D. S., Pauls, D. I., et al (1987) Bipolar affective disorders linked to DNA markers on chromosome 11. Nature, 325, 783–787.CrossRefGoogle ScholarPubMed
Farmer, A. N., McGuffin, P. & Gottesman, I. I. (1987) Twin concordance for DSM–III schizophrenia: scrutinizing the validity of the definition. Archives of General Psychiatry, 44, 634–641.CrossRefGoogle ScholarPubMed
Feighner, J. P., Robins, E., Guze, S. B., et al (1972) Diagnostic criteria for use in psychiatric research. Archives of General Psychiatry, 26, 57–63.CrossRefGoogle ScholarPubMed
Francos, E., Athanassenas, G., Tsitourides, S., et al (1985) Prevalence of DSM–III schizophrenia among the first-degree relatives of schizophrenic probands. Acta Psychiatrica Scandinavica, 72, 382–386.CrossRefGoogle Scholar
Gershon, E. S., Mendlewicz, J., Gastpar, M., et al (1980) A collaborative study of genetic linkage of bipolar manic-depressive illness and red/green color blindness. Acta Psychiatrica Scandinavica, 61, 319–338.CrossRefGoogle Scholar
Gershon, E. S., & Rieder, R. O. (1980) Are mania and schizophrenia genetically distinct? In Mania: An Evolving Concept (eds Belmaker, R. H. & van Praag, H. M.), pp. 97–109. Jamaica: Spectrum Publications.Google Scholar
Gershon, E. S., DeLisi, L. E., Hamovit, J., et al (1988) A controlled family study of chronic psychoses: schizophrenia and schizoaffective disorder. Archives of General Psychiatry, 45, 328–336.Google Scholar
Gill, M., McKeon, P. & Humphries, P. (1988) Linkage analysis of manic depression in an Irish family using H-ras 1 and INS DNA markers. Journal of Medical Genetics, 25, 634–637.CrossRefGoogle Scholar
Gottesman, I. I. & Bertelsen, A. (1989) Confirming unexpressed genotypes for schizophrenia: risks in the offspring of Fischer's Danish unidentical and fraternal discordant twins. Archives of General Psychiatry, 46, 867–872.Google Scholar
Gureje, O. (1989) Correlates of positive and negative schizophrenic syndromes in Nigerian patients. British Journal of Psychiatry, 155, 628–632.Google Scholar
Gureje, O. & Bambgboye, E. A. (1987) A study of Schneider's first rank symptoms of schizophrenia in Nigerian patients. British Journal of Psychiatry, 150, 867–869.CrossRefGoogle ScholarPubMed
Guze, S. B., Cloninger, C. R., Martin, R. L., et al (1983) A follow-up and family study of schizophrenia. Archives of General Psychiatry, 40, 1273–1276.CrossRefGoogle ScholarPubMed
Hodgkinson, S., Sherrington, R., Gurling, H. M. D., et al (1987) Molecular genetic evidence for heterogeneity in manic depression. Nature, 325, 805–806.Google Scholar
Kendler, K. S. (1988a) The genetics of schizophrenia: an overview. In Handbook of Schizophrenia: Nosology, Epidemiology, and Genetics of Schizophrenia, Volume 3 (eds Tsuang, M. T. & Simpson, J. C.), pp. 437–462. New York: Elsevier.Google Scholar
Kendler, K. S. (1988b) Familial aggregation of schizophrenia and schizophrenia spectrum disorders: evaluation of conflicting results. Archives of General Psychiatry, 45, 377–383.Google Scholar
Kendler, K. S. Gruenberg, A. M. & Tsuang, M. T. (1985) A DSM–III family study of nonschizophrenic psychotic disorders. American Journal of Psychiatry, 143, 1098–1105.Google Scholar
Kendler, K. S. Gruenberg, A. M. & Tsuang, M. T. (1986) Psychiatric illness in first degree relatives of schizophrenic and surgical control patients: a family history study using DSM–III criteria. Archives of General Psychiatry, 42, 770–779.Google Scholar
Makanjuola, R. C. A. (1985) Recurrent unipolar manic disorder in the Yoruba Nigerian: further evidence. British Journal of Psychiatry, 147, 434–437.CrossRefGoogle ScholarPubMed
Makanjuola, R. C. A. (1989) Socio-cultural parameters in Yoruba Nigerian patients with affective disorders. British Journal of Psychiatry, 155, 337–340.Google Scholar
Makanjuola, R. C. A. & Adedapo, S. A. (1987) The DSM–III concepts of schizophrenic disorder and schizophreniform disorder: a clinical and prognostic evaluation. British Journal of Psychiatry, 151, 611–618.Google Scholar
Mendlewicz, J., Fleiss, J. L., Cataldo, M., et al (1975) Accuracy of the family history method in affective illness. Archives of General Psychiatry, 32, 309–314.CrossRefGoogle ScholarPubMed
Mendlewicz, J., Simon, P., Sevy, S., et al (1987) Polymorphic DNA marker and X chromosome and manic depression. Lancet, ii, 1230–1232.Google Scholar
Perris, C. (1968) Genetic transmission of depressive psychoses. Acta Psychiatrica Scandinavica Supplement, 203, 45–52.CrossRefGoogle ScholarPubMed
Pope, H. G., Jones, J. M., Cohen, B. M., et al (1982) Failure to find evidence of schizophrenia in first-degree relatives of schizophrenic probands. American Journal of Psychiatry, 139, 826–828.Google Scholar
Reich, T., Cloninger, C. R. & Guze, S. B. (1975) The multifactorial model of disease transmission: I. Description of the model and its use in psychiatry. British Journal of Psychiatry, 127, 1–10.Google Scholar
Rice, J., Reich, T., Andreasen, N. C., et al (1987) The familial transmission of bipolar illness. Archives of General Psychiatry, 44, 441–447.CrossRefGoogle ScholarPubMed
Robins, L. N., Wing, J., Wittchen, H. U., et al (1988) The composite international diagnostic interview. Archives of General Psychiatry, 45, 1069–1077.CrossRefGoogle ScholarPubMed
Sartorius, N., Jablensky, A., Korten, A., et al (1986) Early manifestations and first-contact incidence of schizophrenia in different cultures. Psychological Medicine, 16, 909–928.CrossRefGoogle ScholarPubMed
Scharfetter, C. & Nusperli, M. (1980) The group of schizophrenias, schizoaffective psychoses and affective disorders. Schizophrenia Bulletin, 6, 586–591.Google Scholar
Spitzer, R. L., Endicott, J. & Robins, E. (1978) Research diagnostic criteria: rationale and reliability. Archives of General Psychiatry, 35, 773–782.Google Scholar
Thompson, W. D., Orvaschel, H., Prusoff, B. A., et al (1982) An evaluation of the family history method for ascertaining psychiatric disorders. Archives of General Psychiatry, 39, 53–58.Google Scholar
Tsuang, M. T., Gilberton, M. W. & Faraone, S. V. (1991) The genetics of schizophrenia: current knowledge and future directions. Schizophrenia Research, 4, 157–171.Google Scholar
Weissman, M. M., Kidd, K. K. & Prusoff, B. A. (1982) Variability in rates of disorders in relatives of depressed and normal probands. Archives of General Psychiatry, 39, 1397–1403.CrossRefGoogle ScholarPubMed
Weissman, M. M., Merikangas, K. R., Pauls, D. L., et al (1983) Heritability of schizophrenia. American Journal of Psychiatry, 140, 171–175.Google Scholar
Zimmerman, M., Coryell, W., Pfohl, B., et al (1988) The reliability of the family history method for psychiatric diagnoses. Archives of General Psychiatry, 45, 320–322.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.