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Haloperidol-Induced Changes in Blink Rates Correlate with Changes in BPRS Score

Published online by Cambridge University Press:  29 January 2018

Craig N. Karson ,
Llewellyn B. Bigelow ,
Joel E. Kleinman ,
Daniel R. Weinberger  and
Richard Jed Wyatt
Craig N. Karson
Affiliation:
Division of Special Mental Health, Intramural Research Program, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, DC 20032, USA
Llewellyn B. Bigelow
Affiliation:
Division of Special Mental Health, Intramural Research Program, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, DC 20032, USA
Joel E. Kleinman
Affiliation:
Division of Special Mental Health, Intramural Research Program, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, DC 20032, USA
Daniel R. Weinberger
Affiliation:
Division of Special Mental Health, Intramural Research Program, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, DC 20032, USA
Richard Jed Wyatt
Affiliation:
Division of Special Mental Health, Intramural Research Program, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, DC 20032, USA
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Summary

Spontaneous eye blink rates, psychiatric symptoms and response to neuroleptic medication may all be mediated by dopamine. Fixed doses of haloperidol, a dopamine blocking agent, were administered for six weeks to 17 chronic schizophrenic patients who had been previously withdrawn from all medications. The change in blink rates caused by haloperidol corresponded to a change in the thought disturbance syndrome which measures positive symptoms (r =.48, P <.05). The relationship was particularly clear in patients with normal cerebral ventricles (r =.74, P <.01).

Type
Research Article
Information
The British Journal of Psychiatry , Volume 140 , Issue 5 , May 1982 , pp. 503 - 507
Copyright
Copyright © Royal College of Psychiatrists, 1982 

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