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Further Studies of Vanadium in Depressive Psychosis

Published online by Cambridge University Press:  02 January 2018

G. J. Naylor ,
F. M. Corrigan ,
A. H. W. Smith ,
P. Connelly  and
N. I. Ward
G. J. Naylor*
Affiliation:
Department of Psychiatry
A. H. W. Smith
Affiliation:
Royal Dundee Liff Hospital
P. Connelly
Affiliation:
Department of Mental Health, University of Aberdeen; Lochgilphead
N. I. Ward
Affiliation:
Department of Chemistry, University of Surrey
*
∗Royal Dundee Liff Hospital, Dundee DD2 5NF
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Abstract

Three studies are reported. In study 1, vanadium concentration was estimated by neutron activation analysis in hair, whole blood, serum and urine from 13 patients suffering from depressive psychosis and then when on recovery- Vanadium concentration of hair, whole blood and serum decreased significantly with recovery, but there was no significant change in 24-h urinary excretion or in renal clearance of vanadium. In study 2, vanadium concentration was estimated by neutron activation analysis in serum and urine of 31 patients with depressive psychosis and of 27 normal controls. Mean renal clearance of vanadium was significantly lower and mean serum vanadium concentration significantly higher in depressed patients than in controls. Mean 24-h excretion of vanadium did not differ between the two groups. Vanadium excretion did not correlate with urine volume, with serum concentration or with age. In study 3, erythrocyte Na-K ATPase activity and serum vanadium concentrations were estimated in 58 patients. There was a strong negative correlation between the two, supporting the suggestion that changes in tissue vanadium concentration may explain the changes in sodium transport which occur in depressive psychosis.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 150 , Issue 5 , May 1987 , pp. 656 - 661
Copyright
Copyright © 1987 The Royal College of Psychiatrists 

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References

Ali, S. A., Peet, M. & Ward, N. I. (1985) Blood levels of vanadium, caesium and other elements in depressive patients. Journal of Affective Disorders, 9, 187–191.Google Scholar
Beck, A. T., Ward, C. H., Mendelson, M., Mock, J. & Erbaugh, J. (1961) An inventory for measuring depression. Archives of General Psychiatry, 4, 561–571.CrossRefGoogle ScholarPubMed
Bonting, S. L. (1970) Sodium-potassium activated adenosinetri-phosphatase and cation transport. In Membranes and Ion Transport, Vol. 1, (ed. E. E. Bittar). New York: Wiley Interscience.Google Scholar
Cantley, L. C., Josephson, L., Warner, R., Yanagisawa, M., Lechene, C. & Guidotti, G. (1977). Vanadate is a potent (Na-K) ATPase inhibitor found in ATP derived from muscle. Journal of Biological Chemistry, 252, 7421–7423.CrossRefGoogle ScholarPubMed
Carney, M. W. P., Roth, M. & Garside, R. F. (1965) The diagnosis of depressive syndromes and the prediction of ECT response. British Journal of Psychiatry, 111, 659–674.CrossRefGoogle Scholar
Conri, C., Simonoff, M., Fleury, B. & Moreau, F. (1986) Does vanadium play a role in depressive states? Biological Psychiatry, 21, 546–548.CrossRefGoogle ScholarPubMed
Coppen, A. J. (1960) Abnormality of the blood cerebrospinal fluid barrier of patients suffering from a depressive illness. Journal of Neurology, Neurosurgery and Psychiatry, 23, 156–161.CrossRefGoogle ScholarPubMed
Coppen, A. J. & Shaw, D. M. (1963) Mineral metabolism in melancholia. British Medical Journal, 2, 1439–1444.CrossRefGoogle ScholarPubMed
Dick, D. A. T., Dick, E. G. & Tosteson, D. L. (1969) Inhibition of adenosine triphosphatase in sheep red cell membranes by oxidised glutathione. Journal of General Physiology, 54, 123–133.CrossRefGoogle Scholar
Dick, D. A. T., Naylor, G. J. & Dick, E. G. (1982) Plasma vanadium concentration in manic depressive illness. Psychological Medicine, 12, 533–537.Google Scholar
Feighner, J. P., Robins, E., Guze, S. B., Woodruff, R. A., Winokur, G. & Munoz, R. (1972) Diagnostic criteria for use in psychiatric research. Archives of General Psychiatry, 26, 57–63.Google Scholar
Glen, A. I. M., Ongley, G. C. & Robinson, K. (1969) Diminished membrane transport in manic depressive psychosis and recurrent depression. Lancet, 2, 241–243.Google Scholar
Kay, D. S. G., Naylor, G. J., Smith, A. H. W. & Greenwood, C. (1984) The therapeutic effect of ascorbic acid and EDTA in manic depressive psychosis: double blind comparisons with standard treatments. Psychological Medicine, 14, 533–539.Google Scholar
Nadi, N. S., Nurnberger, J. L. & Gershon, E. S. (1984) Muscarinic cholinergic receptors on skin fibroblasts in familial affective disorder. The New England Journal of Medicine, 11, 225–230.CrossRefGoogle Scholar
Naylor, G. J. (1984) Reversal of Vanadate Induced Inhibition of Na-K ATPase. Journal of Affective Disorder, 8, 91–93.CrossRefGoogle Scholar
Naylor, G. J. & Smith, A. H. W. (1981a) Vanadium, a possible aetiological factor in manic depressive illness. Psychological Medicine, 11, 249–256.CrossRefGoogle ScholarPubMed
Naylor, G. J. & Smith, A. H. W. (1981b) Methylene blue. A new treatment for manic depressive psychosis. IRCS Med Sci, 9, 1154–155.Google Scholar
Naylor, G. J. & Smith, A. H. W. (1981c) Defective genetic control of sodium pump density in manic depressive psychosis. Psychological Medicine, 11, 257–263.CrossRefGoogle ScholarPubMed
Naylor, G. J., McNamee, H. B. & Moody, J. P. (1971) Changes of erythrocyte sodium and potassium on recovery from a depressive illness. British Journal of Psychiatry, 118, 219–223.Google Scholar
Naylor, G. J., Dick, D. A. T., Dick, E. G., Le Poidevin, D. & Whyte, S. F. (1973) Erythrocyte membrane cation carrier in manic depressive illness. Psychological Medicine, 3, 502–508.Google Scholar
Naylor, G. J., Smith, A. H. W., Dick, E. G., Dick, D. A. T., McHarg, A. M. & Chambers, C. A. (1980) Erythrocyte membrane cation carrier in manic depressive psychosis. Psychological Medicine, 10, 521–525.Google Scholar
Naylor, G. J., Dick, D. A. T., Johnston, B. B., Hopwood, S. E., Dick, E. G., Smith, A. H. W. & Kay, D. S. G. (1981) Possible explanation for therapeutic action of lithium and a possible substitute -(Methylene blue). Lancet, 2, 1175–1176.Google Scholar
Naylor, G. J., Smith, A. H. W., Bryce-Smith, D. & Ward, N. I. (1984) Tissue vanadium levels in manic depressive psychosis. Psychological Medicine, 14, 767–772.CrossRefGoogle ScholarPubMed
Peet, M. (1975) The potential difference across the rectal mucosa during depressive illness and lithium therapy. British Journal of Psychiatry, 127, 144–148.Google Scholar
Ward, N. I. (1983) Multi-element analysis of urine by neutron activation analysis. ICRC Report, (Available ICRC, Si 1 wood Park, Ascot, Berkshire SL5 7PY).Google Scholar
Ward, N. I. & Ryan, D. E. (1979) Trace analysis of blood by neutron activation analysis. Analytics Chimica Acta, 105, 185–197.CrossRefGoogle Scholar
Ward, N. I., Stephens, R. & Ryan, D. E. (1979) Comparison of three analytical methods for the determination of trace elements in whole blood. Analytica Chimica Acta, 110, 9–19.Google Scholar
Witkowska, D. & Brzyzwiski, J. (1979) Alteration in brain noradrenaline, dopamine and 5-hydroxytryptamine levels during vanadium poisoning. Polish Journal of Pharmacology, 31, 393–398.Google Scholar
Wright, A. F., Crighton, D. N., Louden, J. B., Morton, J. E. N. & Steel, C. M. (1984) β-adrenoceptor binding defects in cell lines from families with manic depressive disorder. Annals of Human Genetics, 48, 201–214.Google Scholar
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