Hostname: page-component-78c5997874-fbnjt Total loading time: 0 Render date: 2024-11-19T02:08:15.512Z Has data issue: false hasContentIssue false

Fasting Blood Lipid Concentrations in Manic-Depressive Psychosis

Published online by Cambridge University Press:  29 January 2018

R. P. Hullin
Affiliation:
University of Leeds, and Director, Metabolic Research Unit, High Royds Hospital, Menston, Ilkley, Yorkshire
G. Court
Affiliation:
Department of Biochemistry, University of Leeds

Extract

Human blood plasma normally contains 500–1,000 mg./100 ml. of lipid material kept in solution by complex formation in various proportions with protein to form lipoproteins of definite size and constitution. Apart from the chylomicrons at least four β-lipoproteins and two α-lipoproteins are recognized, differing from each other in density. The α-lipoproteins correspond to the α-globulins and the β-lipoproteins to the β-globulins as determined by paper electrophoresis. The various lipoproteins have been shown to possess a constant and characteristic pattern both in protein: lipid ratio and in the relative proportions of phospholipid, sterol, sterol esters and glycerides (Jones et al, 1951; Bragdon et al., 1956). The proportions in which the fatty acids are present have also been shown to be constant (Lindgren et al., 1959).

Type
Research Article
Copyright
Copyright © Royal College of Psychiatrists, 1970 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Bragdon, J. H., Havel, R. J., and Boyle, E. (1956). ‘Human serum lipoproteins. I. Chemical composition of four fractions.’ Journal of Laboratory and Cluneal Medicine, 48, 3642.Google ScholarPubMed
Bridges, P. K., and Jones, M. T. (1966). ‘The diurnal rhythm of plasma Cortisol concentration in depression.’ British Journal of Psychiatry, 112, 1257.CrossRefGoogle ScholarPubMed
Doig, R. J., Mummery, R. V., Wills, M. R., and Elkes, A. (1966). ‘Plasma Cortisol levels in depression.’ British Journal of Psychiatry, 112, 1263–7.CrossRefGoogle ScholarPubMed
Hullin, R. P., Bailey, A. D., McDonald, R., Dransfield, G. A., and Milne, H. B. (1967a). ‘Body water variations in manic-depressive psychosis.’ British Journal of Psychiatry, 113, 584–92.Google ScholarPubMed
Hullin, R. P., Bailey, A. D., McDonald, R., Dransfield, G. A., and Milne, H. B. (1967b). ‘Variations in 11-hydroxycorticosteroids in depression and manic-depressive psychosis.’ British Journal of Psychiatry, 113, 593600.CrossRefGoogle Scholar
Jones, H. B., Gofman, J. W., Lindgren, F. T., Lyon, T. P., Graham, D. M., Strisower, B., and Nichols, A. V. (1951). ‘Lipoproteins in atherosclerosis.’ American Journal of Medicine, 11, 358–80.CrossRefGoogle ScholarPubMed
Keys, A., Anderson, J. T., and Grande, F. (1957). ‘Essential fatty acids, degree of unsaturation, and effect of corn (maize) oil on the serum cholesterol level in man.’ Lancet, i, 66–8.Google Scholar
Lindgren, F. T., Nichols, A. V., Hayes, T. L. Freeman, N. K., and Gofman, J. W. (1959). ‘Structure and homogeneity of the low-density serum lipoproteins.’ Annals of the New York Acadamy of Sciences, 72, 826–44.CrossRefGoogle ScholarPubMed
Lindholm, H. (1956). ‘Studies in normal adults for variations in serum lipids with sex, age, relative body weight and with body-build.’ Scandinavian Journal of Laboratory and Clinical Investigation, 8, suppl. 23, 173.Google ScholarPubMed
McFarland, H. R. (1963). ‘Addison's disease and related psychoses.’ Comprehensive Psychiatry, 4, 90–5CrossRefGoogle Scholar
Verheyden, J., and Nys, J. (1962). ‘The estimation of fatty acid esters in serum by the hydroxamate method.’ Clinica Chimica Acta, 7, 262–69.CrossRefGoogle ScholarPubMed
Woodbury, D. M. (1958). ‘Relation between the adrenal cortex and the central nervous system.’ Pharmacological Reviews, 10, 275357.Google ScholarPubMed
Submit a response

eLetters

No eLetters have been published for this article.