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Familial Pre-senile Dementia: The Relevance of a Histological Diagnosis of Pick's Disease

Published online by Cambridge University Press:  29 January 2018

Myre Sim  and
R. N. Bale
Myre Sim
Affiliation:
United Birmingham Hospitals, Queen Elizabeth Hospital, Birmingham, B15 2TH
R. N. Bale
Affiliation:
St. James' Hospital, Portsmouth, PO4 8LD: United Birmingham Hospitals
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Extract

The literature of familial pre-senile dementia is adequately reviewed by McMenemey (1963) and Pratt (1967) and that on familial forms of Alzheimer's disease by Tandy and Bain (1970). In non-familial cases of Alzheimer's disease it has been possible to correlate the clinical features with the histological diagnosis obtained from cerebral biopsy (Sim and Sussman, 1962; Sim et al., 1966), and the present paper is an attempt to see whether, by using similar diagnostic criteria as listed in Table I, including cerebral biopsy, a similar consistency could be demonstrated in the affected members of each family.

Type
Abstract
Information
The British Journal of Psychiatry , Volume 122 , Issue 571 , June 1973 , pp. 671 - 673
Copyright
Copyright © Royal College of Psychiatrists, 1973 

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References

McMenemey, W. H. (1963). ‘The dementias and progressive diseases of the basal ganglia’, in Greenfield's Neuropathology, pp. 520–76 (ed. Blackwood, W.).Google Scholar
Pratt, R. T. C. (1967). The Genetics of Neurological Disorders. London: Oxford University Press.Google Scholar
Sim, M., and Sussman, I. (1962). ‘Alzheimer's disease: its natural history and differential diagnosis.’ J. nerv. ment. Dis., 104, 593.Google Scholar
Sim, M., Turner, E., and Smith, W. T. (1966). ‘Cerebral biopsy in the investigation of pre-senile dementia. 1. Clinical aspects.’ Brit. J. Psychiat., 112, 119.Google Scholar
Tandy, P. J., and Bain, B. J. (1970). ‘Alzheimer's disease in siblings.’ Med. J. Austral., ii, 832.Google Scholar
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