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Familial Cosegregation of Major Affective Disorder and Darier's Disease (Keratosis Follicularis)

Published online by Cambridge University Press:  02 January 2018

Nick Craddock ,
Mike Owen ,
Susan Burge ,
Bobby Kurian ,
Phil Thomas  and
Peter McGuffin
Nick Craddock*
Affiliation:
Department of Psychological Medicine, University of Wales College of Medicine, Cardiff CF4 4XN
Mike Owen
Affiliation:
Departments of Psychological Medicine and Medical Genetics, University of Wales College of Medicine, Cardiff CF4 4XN
Susan Burge
Affiliation:
Stoke Mandeville Hospital, Mandeville Road, Aylesbury, Bucks HP21 8AL
Bobby Kurian
Affiliation:
Ysbyty Gwynedd, Bangor, Gwynedd
Phil Thomas
Affiliation:
Meirionydd Mental Health Office, Bron Y Garth Hospital, Penrhyndeudraeth, Gwynedd LL48 6HD
Peter McGuffin
Affiliation:
Department of Psychological Medicine, University of Wales College of Medicine, Cardiff CF4 4XN
*
∗Correspondence
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Abstract

Darier's disease is a rare autosomal dominantly inherited keratosis. This is an account of one family in which there is co-occurrence of major affective disorder and Darier's disease in five members and absence of both disorders in five members. The pedigree is consistent with genetic linkage between the Darier gene and a major autosomal dominant susceptibility locus for major affective disorder. When the Darier's disease gene has been mapped, its chromosomal location will be an interesting candidate locus for linkage studies of major affective disorder.

Type
Peer Review
Information
The British Journal of Psychiatry , Volume 164 , Issue 3 , March 1994 , pp. 355 - 358
Copyright
Copyright © 1994 The Royal College of Psychiatrists 

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