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Extrapyramidal Disorders After Prolonged Phenothiazine Therapy

Published online by Cambridge University Press:  29 January 2018

P. F. Kennedy ,
H. I. Hershon  and
R. J. McGuire
P. F. Kennedy
Affiliation:
Medical Research Council Unit for Epidemiological Studies in Psychiatry, University Department of Psychiatry, Edinburgh 10
H. I. Hershon
Affiliation:
University Hospital (St. James), Leeds
R. J. McGuire
Affiliation:
University Department of Psychiatry, Leeds
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Extract

Motor disorders occurring in association with phenothiazine therapy have been widely appreciated and investigated since the advent of these drugs in the early nineteen-fifties. Published works have indicated that between 20 and 40 per cent of patients treated with phenothiazines exhibit signs of extrapyramidal dysfunction (Denham, 1961; Ayd, 1961). However, the relationship between treatment variables and the frequency of these motor disorders is not a simple one. Many factors are likely to have aetiological significance, and it seems that their occurrence is more a reflection of personal idiosyncrasy than of chemical structure, dosage or duration of treatment (Lancet, 1964).

Type
Research Article
Information
The British Journal of Psychiatry , Volume 118 , Issue 546 , May 1971 , pp. 509 - 518
Copyright
Copyright © Royal College of Psychiatrists, 1971 

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References

Ayd, F. J. (1961). ‘A survey of drug-induced extrapyramidal reactions.’ J. Amer. med. Ass., 175, 1054–60.Google Scholar
Ayd, F. J. (1966). ‘Persistent dyskinesia: a neurologic complication of major tranquillizers.’ International Drug Therapy Newsletter, Vol. I, No. 6.Google Scholar
Chatagnon, P., Chatagnon, C., Wilkin, M. O., Fournier, M., and Lorcy, P. (1961). ‘Syndrome dyskinétique facio-bucco-lingual et choréique avec hémiballisme d'étiologie chlorpromazinique.’ Ann. mêd. psychol., 119, 310–18.Google Scholar
Chien, C., and Dimascio, A. (1967). ‘Drug-induced extrapyramidal symptoms and their relations to clinical efficacy.’ Amer. J. Psyckiat., 123, 1490–98.Google Scholar
Crane, G. E. (1968). ‘Tardive dyskinesia in patients treated with major neuroleptics: a review of the literature.’ Amer. J. Psyckiat., Supplement, 124, 40–8.Google ScholarPubMed
Degkwitz, R., Wenzel, W., Binsack, K. F., Herkert, H., and Luxemburger, O. (1966). ‘Zum Probleme der terminalen extrapyramidalen Hyperkinesen an Hand von 1600 langfristig mit Neuroleptica Behandelten.’ Arzneimittelfarschungy 16, 276–9.Google Scholar
Denham, J. (1961). ‘The implications of extrapyramidal symptoms in the treatment of schizophrenia.’ Rev. Canad. Biol., 20, 545–8.Google Scholar
Evans, J. H. (1965). Lancet, i, 458–60.Google Scholar
Faurbye, A., Rasch, P. J., Petersen, P. B., Brandborg, G., and Pakkenberg, H. (1964). ‘Neurological symptoms in pharmacotherapy of psychoses.’ Acta psychiat. Scand., 40, 10–27.Google Scholar
Freyhan, F. (1961). Neuropharmacology, 2, 189.Google Scholar
Hunter, R., Earl, C. J., and Thornicroft, S. (1964). ‘An apparently irreversible syndrome of abnormal movements following phenothiazine medication.’ Proc. Roy. Soc. Med., 57, 758–62.Google Scholar
Joyston-Beçhal, M. P. (1965). ‘Persistent oral dyskinesia in treatment with phenothiazine derivatives.’ Lancet, i, 600–601.Google Scholar
Lancet, (1964). 2, 245.Google Scholar
McGeer, P. L., Boulding, J. E., Gibson, W. C., and Foulkes, B. G. (1961). ‘Drug-induced extrapyramidal reactions.’ J. Amer. med. Ass., 177, 665–70.Google Scholar
Pryce, I. G., and Edwards, H. (1966). ‘Persistent oral dyskinesia in female mental hospital patients.’ Brit. J. Psychiat., 112, 983–7.CrossRefGoogle ScholarPubMed
Sigwald, J., Bouttier, D., Raymondeaud, C., and Piot, C. (1959). ‘Quatre cas de dyskinésie facio-bucco-lingui-masticatrice à évolution prolongée secondaire à un traitement par les neuroleptiques.’ Rev. Neurol., 100, 751–5.Google Scholar
Uhrbrand, L., and Faurbye, A. (1960). ‘Reversible and irreversible dyskinesia after treatment with perphenazine and chlorpromazine.’ Psychopharmacologia, 1, 408–18.Google Scholar
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