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The Expression of Schizophrenia, Affective Disorder and Vulnerability to Tardive Dyskinesia in an Extensive Pedigree

Published online by Cambridge University Press:  02 January 2018

John L. Waddington  and
Hanafy A. Youssef
John L. Waddington*
Affiliation:
Royal College of Surgeons in Ireland
Hanafy A. Youssef
Affiliation:
St Davnet's Hospital, Monaghan, Ireland
*
∗Royal College of Surgeons in Ireland, St Stephen's Green, Dublin 2, Ireland
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Abstract

The demography, psychiatric morbidity, and motor consequences of long-term neuroleptic treatment in the 14 children born to a father with a family history of chronic psychiatric illness and a mother with a late-onset affective disorder resulting in suicide are documented. Twelve siblings lived to adulthood, nine of whom were admitted to a psychiatric hospital in their second or third decade, and required continuous in-patient care; five remaining in hospital, with long-term exposure to neuroleptics, had chroniC., deteriorating, schizophrenic illness and emergence of movement disorder. Two siblings showed no evidence of psychosis but developed a late-onset affective disorder. The implications for the issues of homotypia, vulnerability to involuntary movements, and interaction with affective disorder are discussed.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 153 , Issue 3 , September 1988 , pp. 376 - 381
Copyright
Copyright © Royal College of Psychiatrists, 1988 

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