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Evidence for a Pseudo-autosomal Locus for Schizophrenia Using the Method of Affected Sibling Pairs

Published online by Cambridge University Press:  02 January 2018

J. Collinge ,
L. E. Delisi ,
A. Boccio ,
E. C. Johnstone ,
A. Lane ,
C. Larkin ,
M. Leach ,
R. Lofthouse ,
F. Owen  and
M. Poulter
...Show all authors
J. Collinge
Affiliation:
Division of Psychiatry, Clinical Research Centre, Harrow
L. E. Delisi
Affiliation:
Department of Psychiatry, State University of New York at Stonybrook, New York, USA
A. Boccio
Affiliation:
Department of Psychiatry, State University of New York at Stonybrook, New York, USA
E. C. Johnstone
Affiliation:
Academic Department of Psychiatry, Royal Edinburgh Hospital, Morningside Park, Edinburgh
A. Lane
Affiliation:
Cluain Mhuire Family Centre, Newtownpark Avenue, Blackrock, Co. Dublin, Ireland
C. Larkin
Affiliation:
Cluain Mhuire Family Centre, Newtownpark Avenue, Blackrock, Co. Dublin, Ireland
M. Leach
Affiliation:
Division of Psychiatry, Clinical Research Centre, Watford Road, Harrow, Middlesex
R. Lofthouse
Affiliation:
Division of Psychiatry, Clinical Research Centre, Watford Road, Harrow, Middlesex
F. Owen
Affiliation:
Division of Psychiatry, Clinical Research Centre, Watford Road, Harrow, Middlesex
M. Poulter
Affiliation:
Division of Psychiatry, Clinical Research Centre, Watford Road, Harrow, Middlesex
T. Shah
Affiliation:
Division of Psychiatry, Clinical Research Centre, Watford Road, Harrow, Middlesex
C. Walsh
Affiliation:
Division of Psychiatry, Clinical Research Centre, Watford Road, Harrow, Middlesex
T. J. Crow*
Affiliation:
Division of Psychiatry, Clinical Research Centre, Watford Road, Harrow, Middlesex
*
∗Division of Psychiatry, Clinical Research Centre, Watford Road, Harrow, Middlesex HA1 3UJ
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Abstract

A susceptibility locus for schizophrenia in the ‘pseudo-autosomal’ region has been proposed on the basis of the reported excess of sex-chromosome aneuploidies (e.g. XXY and XXX) among patients with schizophrenia and the finding that schizophrenic sib-pairs are more often of the same than of the opposite sex. This hypothesis has been tested in 83 sibships with two or more siblings fulfilling Research Diagnostic Criteria for schizophrenia or schizoaffective disorder. Alleles at the pseudo-autosomal telomeric locus DXYS14, which is unlinked with sex, were analysed using the method of affected sib-pairs. Affected sibs shared alleles at DXYS14 more frequently than expected by random Mendelian assortment, supporting genetic linkage between DXYS14 and schizophrenia.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 158 , Issue 5 , May 1991 , pp. 624 - 629
Copyright
Copyright © Royal College of Psychiatrists, 1991 

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