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Electroencephalographic Abnormalities in Monozygotic Twins with Tourette's Syndrome

Published online by Cambridge University Press:  02 January 2018

Thomas M. Hyde ,
Helene A. Emsellem ,
Christopher Randolph ,
Kenneth C. Rickler  and
Daniel R. Weinberger
Thomas M. Hyde*
Affiliation:
Neurology Consultant Services, Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, St Elizabeth's Hospital, Washington, DC 20032
Helene A. Emsellem
Affiliation:
George Washington University Medical Center, Washington, DC 20037
Christopher Randolph
Affiliation:
Neuropsychology Section, Brain Disorders Branch, Intramural Research Program, St Elizabeth's Hospital
Kenneth C. Rickler
Affiliation:
Clinical Brain Disorders Branch, Intramural Research Program, St Elizabeth's Hospital
Daniel R. Weinberger
Affiliation:
Clinical Brain Disorders Branch, Intramural Research Program, St Elizabeth's Hospital, Washington, DC 20032, USA
*
∗Correspondence
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Abstract

The association of attentional, neuropsychological, and behavioural abnormalities with Tourette's syndrome (TS) suggests that the abnormal function of the disorder extends beyond the motor circuits of the basal ganglia. To explore this possibility we studied, with conventional 18-channel electroencephalography, monozygotic twins ranging from 8 to 26 years of age, where at least one member of the twin pair suffered from TS. In nine out of the 11 twin pairs that differed in clinical severity of the tic disorder, the twin with the more severe course of illness had a significantly more abnormal electroencephalogram (EEG) by qualitative visual analysis. Most of the differences were due to excessive frontocentral theta activity, suggesting dysfunction outside the basal ganglia. There was also a significant relationship between a lower global neuropsychological testing score and a worse overall EEG. In eight of nine twin sets with different global neuropsychological testing scores, the twin with the lower score had a worse EEG. A similar relationship was found between birth weight and overall EEG quality. In the nine sets that differed in birth weight, the twin with a lower birth weight had a worse EEG in seven of the sets. The EEG findings are unlikely to be a medication effect because the same result was seen in the six twin pairs who had been medication-free for at least six months before entry into the study. The origin of this slowing may relate to the interaction between environmental insults to the central nervous system and the genetic component of TS, an interaction producing damage to the cortex, thalamus, or both.

Type
Papers
Information
The British Journal of Psychiatry , Volume 164 , Issue 6 , June 1994 , pp. 811 - 817
Copyright
Copyright © 1994 The Royal College of Psychiatrists 

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References

Barabas, C., Matthews, W. S. & Holowinsky, M. (1984) Electroencephalographic abnormalities in Tourette's syndrome. Annals of Neurology, 16, 93–94.Google Scholar
Bergen, D., Tanner, C. M. & Wilson, R. (1982) The electroencephalogram in Tourette syndrome. Annals of Neurology, 11, 382–385.Google Scholar
Bonnet, K. A. (1982) Neurobiological dissection of Tourette syndrome: a neurochemical focus on a human neuroanatomical model. In Gilles de la Tourette Syndrome (eds Friedhoff, A. J. & Chase, T. N.), pp. 77–82. New York: Raven Press.Google Scholar
Dasberg, H. & Robinson, D. (1971) Electroencephalographic variations following anti-psychotic drug treatment. Diseases of the Nervous System, 32, 472–478.Google Scholar
Devinsky, O. (1983) Neuroanatomy of Gilles de la Tourette's syndrome. Archives of Neurology, 40, 508–514.Google Scholar
Drake, M. E., Hietter, S. A., Padamadan, H., et al (1991) Computerized EEG frequency analysis in Gilles de la Tourette syndrome. Clinical Electroencephalography, 22, 250–253.Google Scholar
Escalar, G., Majeron, M. A., Finavera, L., et al (1972) Contribute alla conoscenza della sindrome di Gilles de la Tourette. Minerva Medica, 63, 3517–3522.Google Scholar
Feild, J. R., Corbin, K. B., Goldstein, N. P., et al (1966) Gilles de la Tourette's syndrome. Neurology, 16, 453–462.Google Scholar
Galderisi, S., Mucci, A., Mignone, M. L., et al (1992) CEEG mapping in drug-free schizophrenics: differences from healthy subjects and changes induced by haloperidol treatment. Schizophrenia Research, 6, 15–24.Google Scholar
Goetz, C. & Tanner, C. M. (1990) Gilles de la Tourette's syndrome in twins: clinical and neurochemical data. Movement Disorders, 5, 173–175.Google Scholar
Haber, S. N., Kowall, N. W., Vonsattel, J. P., et al (1986) Gilles de la Tourette's syndrome: a postmortem neuropathological and immunohistochemical study. Journal of the Neurological Sciences, 75, 225–241.Google Scholar
Hyde, T. M., Aaronson, B. A., Randolph, C., et al (1992) Relationship of birth weight to the phenotypic expression of Gilles de la Tourette's syndrome in monozygotic twins. Neurology, 42, 652–658.Google Scholar
Ifscen, (1974) A glossary of terms commonly used by clinical electroencephalographers. Electroencephalography and Clinical Neurophysiology, 37, 538–548.Google Scholar
Itil, T. M. (1982) Psychotropic drugs and the human EEG. In Electroencephalography: Basic Principles, Clinical Applications, and Related Fields (eds Niedemeyer, E. & Silva, F. L.), pp. 499–513. Baltimore, MD: Urban and Schwarzenberg.Google Scholar
Krumholtz, A., Singer, H. S., Niedermeyer, E., et al (1983) Electrophysiological studies in Tourette's syndrome. Annals of Neurology, 14, 638–641.Google Scholar
Kurlan, R. (1989) Tourette syndrome: current concepts. Neurology, 39, 1625–1630.CrossRefGoogle ScholarPubMed
Leckman, J. F., Price, R. A., Walkup, J. T., et al (1987) Nongenetic factors in Gilles de la Tourette's syndrome. Archives of General Psychiatry, 44, 100.Google ScholarPubMed
Lees, A. J., Robertson, M., Trimble, M. R., et al (1984) A clinical study of Gilles de la Tourette syndrome in the United Kingdom. Journal of Neurology, Neurosurgery and Psychiatry, 47, 1–8.CrossRefGoogle ScholarPubMed
Linkowski, P., Kerkhofs, M. N., Hauspie, R., et al (1989) EEG sleep patterns in man: a twin study. Electroencephalography and Clinical Neurophysiology, 73, 279–284.Google Scholar
Linkowski, P., Kerkhofs, M. N., Hauspie, R., et al (1991) Genetic determinants of EEG sleep: a study of twins living apart. Electroencephalography and Clinical Neurophysiology, 79, 114–118.CrossRefGoogle ScholarPubMed
Lucas, A. R. & Rodin, E. A. (1973) Electroencephalogram in Gilles de la Tourette's disease. Diseases of the Nervous System, 34, 85–89.Google Scholar
Lykken, D. T., Tellegen, A. & Thorkelson, K. (1974) Genetic determination of EEG frequency spectra. Biological Psychology, 1, 245–259.CrossRefGoogle ScholarPubMed
Min, S. K. & Lee, H. (1986) Gilles de la Tourette's syndrome in Korea. British Journal of Psychiatry, 149, 644–647.CrossRefGoogle ScholarPubMed
Neufeld, M. Y., Berger, Y., Chapman, J., et al (1990) Routine and quantitative EEG analysis in Gilles de la Tourette's syndrome. Neurology, 40, 1837–1839.Google Scholar
Radermecker, F. J. (1977) Degenerative diseases of the central nervous system. In Handbook of Electroencephalography and Clinical Neurophysiology (ed. Remond, A.), pp. 162–191. Amsterdam: Elsevier.Google Scholar
Randolph, C., Hyde, T. M., Gold, J. M., et al (1993) Tourette's syndrome in monozygotic twins: relationship of the tic severity to neuropsychological function. Archives of Neurology, 50, 725–728.Google Scholar
Regeur, L., Pakkenberg, B., Fog, R., et al (1986) Clinical features and long-term treatment with pimozide in 65 patients with Gilles de la Tourette's syndrome. Journal of Neurology, Neurosurgery and Psychiatry, 49, 791–795.CrossRefGoogle ScholarPubMed
Robertson, M. M., Trimble, M. R. & Lees, A. J. (1988) The psychopathology of the Gilles de la Tourette syndrome. British Journal of Psychiatry, 152, 383–390.Google Scholar
Shapiro, A. K., Shapiro, E., Wayne, H. L., et al (1973) Tourette's syndrome: summary of data on 34 patients. Psychosomatic Medicine, 35, 419–435.Google Scholar
Stassen, H. H., Bomben, G. & Propping, P. (1987) Genetic aspects of the EEG: an investigation into the within-pair similarity of monozygotic and dizygotic twins with a new method of analysis. Electroencephalography and Clinical Neurophysiology, 66, 489–501.Google Scholar
Sweet, R. D., Solomon, G. E., Wayne, H., et al (1973) Neurological features of Gilles de la Tourette's syndrome. Journal of Neurology, Neurosurgery and Psychiatry, 36, 1–9.Google Scholar
Ungher, J., Ciurea, E. & Volanschi, D. (1962) EEG analysis of motor neurosis in children (infantile tics). Electroencephalography and Clinical Neurophysiology, 14, 138–149.Google Scholar
Van Woerkom, T. C. A. M., Fortgens, C., Rompel-Martens, C. M. C., et al (1988) Auditory evoke-related potentials in adult patients with Gilles de la Tourette's syndrome in the oddball paradigm. Electroencephalography and Clinical Neurophysiology, 71, 443–449.Google Scholar
Verma, N. P., Syrigou-Papavasiliou, A. & LeWitt, P. A. (1986) Electroencephalographic findings in unmedicated, neurologically and intellectually intact Tourette syndrome patients. Electroencephalography and Clinical Neurophysiology, 564, 12–20.Google Scholar
Vieregge, P., Schäfer, C. & Jörg, J. (1988) Concordant Gilles de la Tourette's syndrome in monozygotic twins: a clinical, neurophysiological and CT study. Journal of Neurology, 235, 366–367.Google Scholar
Visser, S. L., Van Tilburg, W., Hooijer, C., et al (1985) Visual evoked potentials in senile dementia and in nonorganic behavioural disorders in the elderly; comparison with EEG parameters. Electroencephalography and Clinical Neurophysiology, 60, 115–121.Google Scholar
Vogel, F. & Motulsky, A. G. (1986) Human Genetics, pp. 578–585. New York: Springer-Verlag.Google Scholar
Volkmar, F. R., Leckman, J. F., Detlor, J., et al (1984) EEG abnormalities in Tourette's syndrome. Journal of the American Academy of Child Psychiatry, 23, 352–353.Google Scholar
Waserman, J., Lal, S. & Gauthier, S. (1983) Gilles de la Tourette's syndrome in monozygotic twins. Journal of Neurology, Neurosurgery and Psychiatry, 46, 75–77.CrossRefGoogle ScholarPubMed
Wayne, H. L., Shapiro, A. K. & Shapiro, E. (1972) Gilles de la Tourette's syndrome: electroencephalographic investigation and clinical correlation. Clinical Electroencephalography, 3, 160–168.Google Scholar
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