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Efficacy and Tolerability of Moclobemide Compared with Imipramine in Depressive Disorder (DSM-III): An Austrian Double-blind, Multicentre Study∗

Published online by Cambridge University Press:  06 August 2018

U. Baumhackl ,
K. Bizière ,
R. Fischbach ,
Ch. Geretsegger ,
G. Hebenstreit ,
E. Radmayr  and
M. Stabl
U. Baumhackl
Affiliation:
A. Ö. Krankenhaus St Pölten, Abteilung für Neurologie und Psychiatrie, Pölten, Austria
K. Bizière
Affiliation:
F. Hoffmann-La Roche Ltd, Basel, Switzerland
R. Fischbach
Affiliation:
Landes-Nervenklinik, Neurologie Abteilung, Salzburg, Austria
Ch. Geretsegger
Affiliation:
Landes-Nervenklinik, Psych. Krankenabteilung, Salzburg, Austria
G. Hebenstreit
Affiliation:
Nö Landeskrankenhaus für Psychologie und Neurologie, Mauer b. Amstetten, Austria
E. Radmayr
Affiliation:
Facharzt für Neurologie, Dornbirn, Austria
M. Stabl
Affiliation:
F. Hoffmann-La Roche Ltd, Basel, Switzerland
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Abstract

The antidepressant efficacy, tolerability, and safety of moclobemide, a reversible, monoamine oxidase-A inhibitor, were compared with those of imipramine in parallel groups of patients with a major depressive episode, in a 4-week, multicentre (17 centres), randomised study. A total of 381 patients were randomly allocated to either treatment; they were not required to avoid tyramine-rich foods. Drop-out rates were comparable in both groups at about 17%. Judged primarily on the HRSD, no significant differences in efficacy were observed between the groups, but the number of patients presenting with adverse events, as well as the total number of adverse events, was greater with imipramine. Cardiovascular tolerability was satisfactory and physical examination, body weight, and laboratory values were essentially unaffected in both groups.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 155 , Issue S6: Depression and Reversible Monoamine Oxidase Inhibitors-New Perspectives , October 1989 , pp. 78 - 83
Copyright
Copyright © 1989 The Royal College of Psychiatrists 

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