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Effects of Ethanol on the NMR Characteristics of Rat Brain

Acute Administration, Dependency, and Long-Term Effects

Published online by Cambridge University Press:  02 January 2018

J. A. O. Besson ,
S. G. Greentree ,
M. A. Foster  and
J. E. Rimmington
J. A. O. Besson*
Affiliation:
Department of Mental Health
S. G. Greentree
Affiliation:
Department of Mental Health
M. A. Foster
Affiliation:
Department of Biomedical Physics and Bioengineering, University of Aberdeen
J. E. Rimmington
Affiliation:
Department of Biomedical Physics and Bioengineering, University of Aberdeen
*
∗Department of Mental Health, University Medical Buildings, Foresterhill, Aberdeen AB9 2ZD
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Abstract

In rats, neither acute administration of ethanol nor the establishment of ethanol dependence by chronic administration for 28 days produced significant 1H-NMR relaxation changes. However, chronic ethanol intake for six months produced a transient rise in T1, with no change in T2 or water content. The significance of these results for study in man is discussed and a hypothesis is proposed to explain discrepant differences between T1, T2 and water content. It is suggested that T1 change with long-term ethanol exposure is related to altered free/bound water state secondary to cell membrane changes.

Type
Papers
Information
The British Journal of Psychiatry , Volume 155 , Issue 6 , December 1989 , pp. 818 - 821
Copyright
Copyright © The Royal College of Psychiatrists, 1989 

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