Hostname: page-component-cd9895bd7-gvvz8 Total loading time: 0 Render date: 2024-12-22T15:59:30.161Z Has data issue: false hasContentIssue false
  • English
  • Français

A Double-Blind Trial of Phenelzine and Amitriptyline in Depressed Out-Patients. a Possible Differential Effect of the Drugs on Symptoms

Published online by Cambridge University Press:  29 January 2018

D. W. K. Kay ,
R. F. Garside  and
T. J. Fahy
D. W. K. Kay
Affiliation:
Department of Psychological Medicine, Royal Victoria Infirmary and University of Newcastle upon Tyne, Queen Victoria Road, Newcastle upon Tyne, NE1 4LP
R. F. Garside
Affiliation:
St. Loman's Hospital, Palmerstown, Co. Dublin, Republic of Ireland (formerly Senior Research Associate, Department of Psychological Medicine, University of Newcastle upon Tyne)
T. J. Fahy
Affiliation:
St. Loman's Hospital, Palmerstown, Co. Dublin, Republic of Ireland (formerly Senior Research Associate, Department of Psychological Medicine, University of Newcastle upon Tyne)
Get access Rights & Permissions [Opens in a new window]

Extract

It is widely agreed that the MAO inhibitor group of drugs are less effective anti-depressants than the tricyclics in severe depressions, specially those of endogenous type (Medical Research Council, 1965), but a role for them is still claimed, for example, in the treatment of milder depressions or of depressive symptoms. According to Pöldinger (1967) they are ‘thermagasics', i.e. psychic energizers or disinhibitors, and their mood elevating effect is relatively slight. Dally (1965) maintained that MAO inhibitors were most useful in atypical depressions, with tension and anxiety, but were ineffective in patients with inadequate personalities. Kelly et al. (1970) found that these drugs relieved depressive symptoms in phobic anxiety states. In this paper we have attempted to reexamine this question in a double-blind trial of phenelzine and amitriptyline in depressed out-patients.

Type
Papers
Information
The British Journal of Psychiatry , Volume 123 , Issue 572 , July 1973 , pp. 63 - 67
Copyright
Copyright © Royal College of Psychiatrists, 1973 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Beck, A. T., Ward, C. H., Mandelson, M., Mark, J., and Esbauoh, J. (1961). ‘An inventory for measuring depression.’ Arch. gen. Psychiat., 4, 561–71.CrossRefGoogle ScholarPubMed
Carney, M. W. P., Roth, M., and Garside, R. F. (1965). ‘The diagnosis of depressive syndromes and the prediction of E.C.T. response.’ Brit. J. Psychiat., 111, 659–74.CrossRefGoogle ScholarPubMed
Coppen, A., and Metcalfe, M. (1965). ‘Effects of a depressive illness on M.P.I. scores.’ Brit. J. Psychiat., 111, 236–9.Google Scholar
Dally, P. J. (1965). In The Scientific Basis of Drug Therapy in Psychiatry (eds. Marks and Pare), p. 149. London: Pergamon.Google Scholar
Eysenck, H., and Eysenck, S. B. G. (1964). Manual of the Eysenck Personality Inventory. University of London Press.Google Scholar
Garside, R. F., Kay, D. W. K., Roy, J. R., and Beamish, Pamela (1970). ‘M.P.I. scores and symptoms of depression.’ Brit. J. Psychiat., 116, 429–32.CrossRefGoogle ScholarPubMed
Hamilton, M. (1960). ‘A rating scale for depression.’ J. Neurol. Neurosurg. Psychiat., 23, 56–62.CrossRefGoogle ScholarPubMed
Kelly, D., Guirguis, W., Frommer, E., Mitchell-Hoggs, N., and Sargant, W. (1970). ‘Treatment of phobic states with antidepressants.’ Brit. J. Psychiat., 116, 387–98.Google Scholar
Kiloh, L. G., Ball, J. R. B., and Garside, R. F. (1962). ‘Prognostic factors in treatment of depressive states with imipramine.’ Brit. med. J., i, 1225–7.Google Scholar
Lubin, B. (1965). ‘An adjective check list for measurement of depression.’ Arch. gen. Psychiat., 12, 57–62.Google Scholar
M.R.C. Report (1965). ‘Clinical trial of the treatment of depressive illness.’ Brit. med. J., i, 881.Google Scholar
Pöldinger, W. (1967). Compendium of Psychopharmacology. Basle: Hoffmann-La Roche.Google Scholar
Rao, C. R. (1952). Advanced Statistical Methods in Biometric Research, pp. 112–15. New York: John Wiley.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.