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Double-Blind Comparison of Half-Dose and Standard-Dose Flupenthixol Decanoate in the Maintenance Treatment of Stabilised Out-Patients with Schizophrenia

Published online by Cambridge University Press:  02 January 2018

D. A. W. Johnson ,
J. M. Ludlow ,
K. Street  and
R. D. W. Taylor
D. A. W. Johnson*
Affiliation:
The Pastures Hospital, Derby
J. M. Ludlow
Affiliation:
The Pastures Hospital, Derby
K. Street
Affiliation:
Manchester Polytechnic
R. D. W. Taylor
Affiliation:
Manchester Polytechnic
*
∗University Hospital of South Manchester, West Didsbury, Manchester M20 8LR
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Abstract

A double-blind controlled trial of 50% dose reduction in maintenance treatment in stable out-patients with low BPRS scores and good social function shows a significantly higher relapse rate in the low-dose group at 12 months (P < 0.05). After an interval of 24–36 months from dose reduction, 56–76% had experienced a relapse and 76–79% had resumed their former dosage. No clear advantage was shown for the lower dose in either a reduction of side-effects or improved social function, but a reduced prevalence or lower rate of symptom emergence for tardive dyskinesia was suggested.

Type
Papers
Information
The British Journal of Psychiatry , Volume 151 , Issue 5 , November 1987 , pp. 634 - 638
Copyright
Copyright © 1987 The Royal College of Psychiatrists 

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References

Baldessarini, R. J. & Davis, J. M. (1980) What is the best maintenance dose of neuroleptics in schizophrenia? Psychiatric Research, 3, 115–122.CrossRefGoogle ScholarPubMed
Capstick, N. (1980) Long term fluphenazine decanoate maintenance dosage requirements of chronic schizophrenic patients. Acta Psychiatrica Scandinavica, 61, 256–262.CrossRefGoogle ScholarPubMed
Davis, J. M. (1975) Overview: maintenance therapy in psychiatry: 1. Schizophrenia. American Journal of Psychiatry, 132, 1237–1245.Google Scholar
Feighner, J. P., Robins, E., Guze, S. B. et al (1972) Diagnostic criteria for use in psychiatric research. Archives of General Psychiatry, 26, 57–63.CrossRefGoogle ScholarPubMed
Guy, W. (1976) ECDEU Assessment Manual for Psychopharmacology. Rockville, Maryland: US Department of Health, Education and Welfare, National Institute of Mental Health.Google Scholar
Hirsch, S. R., Gaind, R., Rhode, P. D., Stevens, B. C. & Wing, J. K. (1973) Outpatient maintenance of chronic schizophrenic patients with long acting phenothiazine. British Medical Journal, i, 633–637.CrossRefGoogle Scholar
Hogarty, G. E. & Goldberg, S. C. (1973) Drug and sociotherapy in the aftercare of schizophrenic patients. Archives of General Psychiatry, 28, 54–64.CrossRefGoogle ScholarPubMed
Hogarty, G. E. & Goldberg, S. C., Schooler, N. R. et al (1974) Drug and sociotherapy in the aftercare of schizophrenic patients: III. Adjustment of non-relapsed patients. Archives of General Psychiatry, 31, 609–618.Google Scholar
Hogarty, G. E., Ulrich, R. F., Mussare, F. et al (1976) Drug discontinuation among long-term, successfully maintained schizophrenic outpatients. Archives of General Psychiatry, 33, 494–500.Google Scholar
Johnson, D. A. W. (1979) Further observations on the duration of depot neuroleptic maintenance therapy in schizophrenia. British Journal of Psychiatry, 135, 524–530.CrossRefGoogle ScholarPubMed
Johnson, D. A. W. (1984) Observations on the use of long-acting depot neuroleptic injections in the maintenance therapy of schizophrenia. Journal of Clinical Psychiatry, 5, 13–21.Google Scholar
Johnson, D. A. W., Pasterski, G., Ludlow, J. M., Street, K. & Taylor, R. D. W. (1983) The discontinuance of maintenance neuroleptic therapy in chronic schizophrenic patients: drug and social consequences. Acta Psychiatrica Scandinavica, 67, 339–352.CrossRefGoogle ScholarPubMed
Kane, J. M. (1984) The use of depot neuroleptics. Journal of Clinical Psychiatry, 45, 5–12.Google ScholarPubMed
Kane, J. M., Rifkin, A., Quitkin, F., Nayak, D. & Ramos-Lorenzi, J. (1982) Fluphenazine vs. placebo in patients with remitted acute first episode schizophrenia. Archives of General Psychiatry, 39, 70–73.CrossRefGoogle ScholarPubMed
Kane, J. M., Rifkin, A., Quitkin, F., Nayak, D., & Woerner, M. (1983) Low dose neuroleptic treatment of outpatient schizophrenics. Preliminary results for relapse rates. Archives of General Psychiatry, 40, 893–896.Google Scholar
Leff, J. P. & Wing, K. (1971) Trial of maintenance therapy in schizophrenia. British Medical Journal, iii, 559–604.Google Scholar
Marder, S. R., Van Putten, T., Mintz, J., McKenzie, J., Lebell, M., Faltico, G. & May, P. R. (1984) Costs and benefits of two doses of fluphenazine. Archives of General Psychiatry, 41, 1025–1029.CrossRefGoogle ScholarPubMed
Marder, S. R., Van Putten, T., Lebell, M., Faltico, G. & McKenzie, J. (1985) Low dose vs. conventional dose neuroleptic maintenance. Presented at the 1985 American Psychiatric Association Meeting, Dallas, Texas.Google Scholar
Overall, G. E. & Gorham, D. R. (1962) The brief psychiatric rating scale. Psychological Reports, 10, 799.Google Scholar
Rifkin, A., Quitkin, F. & Rabiner, C. J. (1977) Fluphenazine decanoate, fluphenazine hydrochloride given orally and placebo in remitted schizophrenia: relapse rate after one year. Archives of General Psychiatry, 34, 43–47.Google Scholar
Schooler, N. R., Levine, J. & Severe, J. B. (1980) Prevention of relapse in schizophrenia: an evaluation of fluphenazine decanoate. Archives of General Psychiatry, 37, 16–24.CrossRefGoogle ScholarPubMed
Simpson, G. M., Amuse, D., Blair, J. P. & Farkas, T. (1964) Phenothiazine produced extrapyramidal system disturbance. Archives of General Psychiatry, 10, 199–208.Google Scholar
Stevens, B. C. (1973) Role of fluphenazine decanoate in lessening the burden of chronic schizophrenics on the community. Psychological Medicine, 3, 141–158.Google Scholar
Teicher, M. H. & Baldessarini, R. J. (1985) Selection of neuroleptic dose. Archives of General Psychiatry, 42, 636–637.CrossRefGoogle Scholar
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