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A Double-Blind Comparison of Dothiepin and Amitriptyline in Patients with Primary Affective Disorder: Serum Levels and Clinical Response

Published online by Cambridge University Press:  29 January 2018

J. Mendlewicz ,
P. Linkowski  and
J. A. Rees
J. Mendlewicz
Affiliation:
Erasme Hospital, University of Brussels, Route de Lennick, 808, 1070 Brussels, Belgium
P. Linkowski
Affiliation:
Erasme Hospital, University of Brussels, Route de Lennick, 808, 1070 Brussels, Belgium
J. A. Rees
Affiliation:
Research Department, The Boots Company Ltd., Nottingham, England
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Summary

In a double-blind parallel group study, thirty-two patients suffering from a primary affective disorder received either dothiepin or amitriptyline. Serum concentrations of total dothiepin plus northiaden or amitriptyline and nortriptyline were estimated. A similar therapeutic response was seen with both drugs but there was no correlation with serum concentrations of amitriptyline or nortriptyline, whereas serum dothiepin correlated positively with clinical response.

Type
Papers
Information
The British Journal of Psychiatry , Volume 136 , Issue 2 , February 1980 , pp. 154 - 160
Copyright
Copyright © Royal College of Psychiatrists, 1980 

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